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Objective: To determine the effect of oral administration of calcium on plasma and ionized free calcium concentration in healthy adolescent pregnant women.

Methods: In a double blind randomized controlled clinical trial were recruited 48 healthy adolescent pregnant women, 24 (50%) received 600 mg of elemental calcium and 24 (50%) received 600 mg of lactose placebo. At the inclusion time the plasma and intracellular free calcium concentrations were measured by standardized techniques. One month later the plasma and intracellular free calcium concentrations in both groups were measured.

Results: At the inclusion time and one month after treatment both groups were comparable for sociodemographic characteristics and the basal intake of calcium (p=0.92, p=0.62). Calcium supplementation did not modify the concentrations of plasma ionized calcium (1.19+0.04 mmol/l vs. 1.23+0.02 mmol/l, p=0.56) and the free intracellular calcium concentration (mmol/l vs. 89.7 mmol/l, p=0.91); similar effects were observed with the placebo treatment (1.20+0.05 mmol/l vs. 1.19+0.03 mmol/l p=0.86; 116.2 mmol/l vs 137.5 mmol/l, p=0.16, respectively).

Conclusions: Oral administration of 600 mg of elemental calcium in adolescent pregnant women did not induce changes in the plasma and intracellular ionized free calcium concentrations and could explain in part the lack effect of this only supplementation in preeclampsia prevention.

Julián A. Herrera, Universidad del Valle

Profesor Titular y Emérito, Departamento de Medicina Familiar, Escuela de Medicina, Universidad del Valle, Cali, Colombia.

Myriam Arévalo Herrera, Universidad del Valle

Profesora Titular y Emérita, Instituto de Inmunología del Valle, Universidad del Valle, Cali, Colombia.

Adriana Villegas, Laboratorio Asoclinic

Bacterióloga, Laboratorio Asoclinic, Cali, Colombia.

Sócrates Herrera, Universidad del Valle

Profesor Titular, Director Instituto de Inmunología del Valle, Universidad del Valle, Cali, Colombia.

Maribel Villalba, Universidad del Valle

Profesora Asociada, Directora Sección de Radiología, Departamento de Medicina Interna, Escuela de Medicina, Universidad del Valle, Cali, Colombia.

Arnoldo Bromet, Universidad del Valle

Profesor Asistente, Director Departamento de Medicina Familiar, Escuela de Medicina, Universidad del Valle, Cali, Colombia.
Herrera, J. A., Arévalo Herrera, M., Villegas, A., Herrera, S., Villalba, M., & Bromet, A. (2006). Calcium oral supplementation in adolescent pregnant women. Colombia Medica, 37(2 Supl 1), 15–20. https://doi.org/10.25100/cm.v37i2 Supl 1.432

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