@article{Castillo_Pachajoa_Villota_Zurita_Palacios_Gutiérrez_2006, title={Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model.}, volume={37}, url={https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/454}, DOI={10.25100/cm.v37i4.454}, abstractNote={<strong><em>Introduction: </em></strong>There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration. <br /><strong><em>Objective: </em></strong>To determine the anti-secretory effect of the species Cannabis sativa. <br />Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH. <br /><strong><em>Results: </em></strong>The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes. <br /><strong><em>Conclusions: </em></strong>These results suggest that the Cannabis sativa extract diminishes the gastric acid output.}, number={4}, journal={Colombia Medica}, author={Castillo, Germán Gabriel and Pachajoa, Harry Mauricio and Villota, Sandra Eliana and Zurita, Edwin and Palacios, Mauricio and Gutiérrez, Oscar}, year={2006}, month={Nov.}, pages={254–257} }