TY - JOUR AU - Castillo, Germán Gabriel AU - Pachajoa, Harry Mauricio AU - Villota, Sandra Eliana AU - Zurita, Edwin AU - Palacios, Mauricio AU - Gutiérrez, Oscar PY - 2006/11/20 Y2 - 2024/03/28 TI - Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model. JF - Colombia Medica JA - Colomb Med VL - 37 IS - 4 SE - Original Articles DO - 10.25100/cm.v37i4.454 UR - https://colombiamedica.univalle.edu.co/index.php/comedica/article/view/454 SP - 254-257 AB - <strong><em>Introduction: </em></strong>There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration. <br /><strong><em>Objective: </em></strong>To determine the anti-secretory effect of the species Cannabis sativa. <br />Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH. <br /><strong><em>Results: </em></strong>The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes. <br /><strong><em>Conclusions: </em></strong>These results suggest that the Cannabis sativa extract diminishes the gastric acid output. ER -