A cross sectional study of leptospirosis and fetal death in Yucatan, Mexico
Abstract
Introduction:Leptospirosis is a zoonotic disease affecting mainly to low income human population. Acute leptospiral infection during pregnancy has been associated with spontaneous abortion and fetal death during the first trimester and the abortion may occur as consequence of systemic failure.
Objective:To estimate the frequency of Leptospira interrogans infection in women with spontaneous abortion in the state of Yucatan, Mexico.
Methods:A cross sectional study on women with spontaneous abortion was conducted. Serum samples were tested for Leptospirosis by the microaglutination test, to estimate the frequency of the infecting serovar. The indirect ELISA IgM was used to detect recent infection by L. interrogans. DNA was extracted from paraffin-embedded tissue of placenta for PCR detection of L. interrogans.
Results:Overall frequency of infection with L. interrogans in the 81 women with abortion was 13.6%. Five of the 12 serovars evaluated were found and included. Two of the 11 women with abortion and positive to microaglutination test were also positive to the ELISA IgM test. None samples were positive for PCR Leptospira diagnosis.
Conclusion:two women could be associated with spontaneous abortion due to leptospirosis, because they showed antibodies against L. interrogans in the microaglutination test and ELISA IgM assays. Differences between regions were found with respect to the prevalences of lesptospirosis.
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Keywords
- Leptospirosis
- abortion spontaneous
- Leptospira
References
.WHO. Leptospirosis: an emerging public health problem. Weekly Epidemiological Record. 2011;86(6):45–52
Regan L. A prospective study of spontaneous abortion. In: Beard RW and Sharp F (eds). Early Pregnancy Loss: Mechanisms and Treatment. New York: Springer-Verlag,. 1988;23–27
Petrozza JC, Scott RS. Recurrent Early Pregnancy Loss. http://emedicine.medscape.com/article/260495-overview
Faine S, Adler B, Christopher W, Valentine R. Fatal congenital human leptospirosis. Zentralbl Bakteriol Mikrobiol Hyg A. 1984;257:548
Shaked Y, Shpilber O, Samra D, Samra Y. Leptospirosis in pregnancy and its effect on the fetus: Casa report and review. Clin Infect Dis. 1993;17:241–243
Carles G, Montoya E, Joly F, Peneau C. Leptospirosis and pregnancy. Eleven cases in French Guyana. J Gynecol Obstet Biol Reprod (Paris). 1995;24(4):418–421
Noguchi H, Klieger J. Immunological estudies with a strain of Leptospira isolated from a case of yellow fever in Mérida, Yucatan. J Exp Med. 1920;32(5):627–632
Vado-Solís I, Cárdenas-Marrufo MF, Jiménez-Delgadillo B, Alzina-López A, Laviada-Molina H, Suárez-Solís V, Zavala-Velázquez JE. Clinical epidemiological study of Leptospirosis in human and reservoirs in Yucatán, México. Rev Inst Med Trop Sao Paulo. 2002;44(6):335–340
Cárdenas-Marrufo MF, Vado-Solís I, Pérez-Osorio CE, Segura-Correa J. Seropositivity to leptospirosis in domestic reservoirs and detection of Leptospira spp. from water sources, in farms of Yucatan, Mexico. Trop Subtrop Agroecosyt. 2011;14(1):185–189
Vado-Solís IA, Suárez-Solís V, Jiménez-Delgadillo B, Zavala-Velázquez JE, Segura-Correa JC. Toxoplasma gondii presence in women with spontaneous abortion in Yucatan, Mexico. J Parasitol. 2013;99(2):383–385
WHO. Human Leptospirosis. Geneva, Switzerland: WHO; 2003
Haake DA and Levett PN. Leptospirosis in humans. In: Adler B (ed.). Leptospira and Leptospirosis, Current Topics in Microbiology and Inmunology. Berlin Heidelberg: Springer-Verlag,. 2015;665–698
Murgia R, Riquelme N, Baranton G, Cinco M. Oligonucleotides specific for pathogenic and saprophytic Leptospira occurring in water. FEMS Microbiol Lett. 1997;148:27–34
Instituto Mexicano del Seguro Social. Diagnóstico y Tratamiento del Aborto Espontaneo y manejo inicial del Aborto Recurrente. México: CENETEC; 2009
Cassasco G, Di-Pietrantonio E. Aborto Guía de Atención. Rev Hosp Mat Inf Ramón Sarda. 2008;27(1):33–41
Donaires LF, Céspedes MS, Sihuincha MF, Pachas PE. Determinantes ambientales y sociales para la reemergencia de la leptospirosis en la región amazónica del Perú, 2012. Rev Peru Med Exp Salud Publica. 2012;29(2):280–284
Gainder S, Singla R; Dhaliwal L and Suri V. Leptospirosis as a cause of intrauterine fetal demise: short report of rare presentation. Arch Gynecol Obstet. 2010;281(6):1061–1063
Dadhwal V; Bahadur A and Deka D. Leptospirosis as a cause of fever in pregnancy. Int J Gynaecol Obstet. 2007;99(3):252–253
Baytur YB; Cabuk M and Kandiloglu AR. Weil's syndrome in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005;119:132–133
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