SARS-CoV-2 diagnostic testing alternatives for Latin America
Abstract
In the past four months SARS-CoV-2 has reached most countries in the world. Public health strategies based on widespread testing and proper isolation of positive cases have shown to be helpful to reduce local transmission of SARS-CoV-2. Confirmatory tests, that identify viral RNA, and screening serological tests that identify viral antigens or host antibodies against viral proteins are part of the tools that nations can use to fight infectious disease epidemics. Understanding how each test works can provide insights about their test characteristics and how they can be used for different clinical and public health goals. Testing is a key strategy to reduce viral transmission, not only for this epidemic, but also for others to come.
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Keywords
- SARS-CoV-2
- diagnostic
- covid-19
- Severe Acute Respiratory Syndrome
- SARS Virus
- Virus RNA
- Coronavirus
- Quarantine
- RNA-Directed DNA Polymerase
- Viral Proteins
- Nucleocapsid
- Antibodies, Monoclonal
- Point-of-Care Systems
- Pandemics
- Indicators and Reagents
- Immobilized Proteins
References
World Health Organization. Coronavirus disease (COVID-19) technical guidance: Laboratory testing for 2019-nCoV in humans. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance. 2020. Accessed April 6, 2020.
NUS Saw Swee Hock School of Public Health. COVID-19 Science Report: Diagnostics. 2020. Doi: 10.25540/e3y2-aqye. Available from: https://sph.nus.edu.sg/wp-content/uploads/2020/03/COVID-19-Science-Report-Diagnostics-30-Mar.pdf Accessed April 6, 2020.
Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020;323(14):1406-1407. https://doi.org/10.1001/jama.2020.2565
Huang P, Liu T, Huang L, Liu H, Lei M, Xu W, et al. Use of Chest CT in Combination with Negative RT-PCR Assay for the 2019 Novel Coronavirus but High Clinical Suspicion. Radiology. 2020;295(1):22-23. https://doi.org/10.1148/radiol.2020200330
Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020:200343. https://doi.org/10.1148/radiol.2020200343
Foundation for Innovative New Diagnostics (FIND). SARS-COV-2 diagnostic pipeline. 2020. Available from: https://www.finddx.org/covid-19/pipeline/. Accessed April 06, 2020.
Cheng MP, Papenburg J, Desjardins M, Kanjilal S, Quach C, Libman M, et al. Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus-2: A Narrative Review. Ann Intern Med. 2020; https://doi.org/10.7326/M20-1301
Kelly-Cirino C, Mazzola LT, Chua A, Oxenford CJ, Van Kerkhove MD. An updated roadmap for MERS-CoV research and product development: focus on diagnostics. BMJ Glob Health. 2019;4(Suppl 2):e001105. https://doi.org/10.1136/bmjgh-2018-001105
Ospina A. Qué pasa con las pruebas del coronavirus en Colombia?. Caracol Radio. 27/03/2020 19:07 COT. Available from: https://caracol.com.co/radio/2020/03/28/salud/1585353870_152960.html Accessed April 4, 2020.
Cepheid. Xpert® Xpress SARS-CoV-2. has received FDA Emergency Use Authorization. 2020. Available at: https://www.cepheid.com/coronavirus Accessed April 06, 2020.
Abbott press releases. Abbott launches molecular point-of-care test to detect novel coronavirus in as little as five minutes. Available from: https://abbott.mediaroom.com/2020-03-27-Abbott-Launches-Molecular-Point-of- Care-Test-to-Detect-Novel-Coronavirus-in-as-Little-as-Five-Minutes. 2020. Accessed April 06, 2020.
Sheridan, C. Fast, portable tests come online to curb coronavirus pandemic. Nature Biotechnology. March 23, 2020. Updated April 7, 2020. Available from: https://www.nature.com/articles/d41587-020-00010-2 Accessed April 13, 2020.
Gordis L. Epidemology. Fifth ed. Canada: Elsevier Saunders; 2014.
Newsfile. Sona Nanotech Provides a Progress Update on its Covid-19 Antigen Test. Available from: https://www.newsfilecorp.com/release/54361/Sona-Nanotech-Provides-a-Progress-Update-on-its-Covid19-Antigen- Test Accessed: April 13, 2020.
Kumar VS. In Vitro Diagnostic Assays for COVID-19: Recent Advances and Emerging Trends. Diagnostics. 2020;10(202):1-7. https://doi.org/10.3390/diagnostics10040202
Australian Government Department of Health; Therapeutic COVID-19 test kits included on the ARTG for legal supply in Australia. Available from: https://www.tga.gov.au/covid-19-test-kits-included-artg-legal-supply- australia Accessed April 07, 2020.
Tan W, Lu Y, Zhang J, Wang J, Dan Y, Tan Z, et al. Viral kinetics and antibody responses in patients with COVID-19. Medrxiv. 2020; Preprint. https://doi.org/10.1101/2020.03.24.20042382
Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, et al. Development and clinical application of A rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol. 2020; 1-7 https://doi.org/10.1002/jmv.25727
Package Insert. ALLTEST 2019-nCoV IgG/IgM rapid test cassette. Hangzhou, China: Hangzhou ALLTEST Biotech Co., Ltd.; 2020.
Aytu BioScience Secures Exclusive U.S. Distribution Agreement for Coronavirus 2019 (COVID-19) Point-of- Care Rapid Test. Available from: https://www.accesswire.com/579898/Aytu-BioScience-Secures-Exclusive-US- Distribution-Agreement-for-Coronavirus-2019-COVID-19-Point-of-Care-Rapid-Test Accessed April 5, 2020.
Accu-Tell. COVID-19 IgG/IgM Rapid Test Cassette. Available from: https://www.accubiotech.com/product- covid-19-igg-igm-rapid-test-cassette-(whole-blood-serum-plasma).html Accessed April 06, 2020.
Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, et al. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020; 2020.04.25.20074856. https://doi.org/10.1101/2020.04.25.20074856
Shen C, Wang Z, Zhao F, et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. 2020; 323(16):1582-1589. https://doi.org/10.1001/jama.2020.4783
Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. 2020;20(4):398-400. https://doi.org/10.1016/S1473-3099(20)30141-9
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