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  1. Home /
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  3. Vol 40 No 1 (2009) /
  4. Reviews

Neuronal apoptosis: signal and cell diversity

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Abstract

Programmed cell death occurs as a physiological process during development. In the brain and spinal cord this event determines the number and location of the different cell types. In adulthood, programmed cell death or apoptosis is more restricted but it may play a major role in different acute and chronic pathological entities. However, in contrast to other tissues where apoptosis has been widely documented from a morphological point of view, in the central nervous system complete anatomical evidence of apoptosis is scanty. In spite of this there is consensus about the activation of different signal systems associated to programmed cell death. In the present article we attempt to summarize the main apoptotic pathways so far identified in nervous tissue. Considering that apoptotic pathways are multiple, the neuronal cell types are highly diverse and specialized and that neuronal response to injury and survival depends upon tissue context, (i.e., preservation of connectivity, glial integrity and cell matrix, blood supply and trophic factors availability) what is relevant for the apoptotic process in a sector of the brain may not be important in another.

Authors

  • Lina Vanessa Becerra Universidad del Valle
  • Hernán José Pimienta Universidad del Valle

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Keywords

  • Bcl2
  • Anoikis
  • Caspases
  • Neurodegeneration diseases
  • Traumatic injury
  • Ischemia

Author Biography


, Universidad del Valle
Centro de Estudios Cerebrales, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali, Colombia.
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Submitted
2009-12-02
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How to Cite
Becerra, L. V., & Pimienta, H. J. (1). Neuronal apoptosis: signal and cell diversity. Colombia Médica, 40(1), 124-133. https://doi.org/10.25100/cm.v40i1.634
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Issue
Vol 40 No 1 (2009)
Section
Reviews

The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use

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This work is under License Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) .

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