Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model.
Cannabis Gastric juice Cannabinoids Tetrahydrocannabinol
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Introduction: There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration.
Objective: To determine the anti-secretory effect of the species Cannabis sativa.
Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH.
Results: The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes.
Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.
Objective: To determine the anti-secretory effect of the species Cannabis sativa.
Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH.
Results: The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes.
Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.
Castillo, G. G., Pachajoa, H. M., Villota, S. E., Zurita, E., Palacios, M., & Gutiérrez, O. (2006). Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model. Colombia Medica, 37(4), 254–257. https://doi.org/10.25100/cm.v37i4.454
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