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Case description:
The first human case of infection with the Rickettsia parkeri Atlantic Rainforest strain in an 8-year-old male patient in an urban environment is presented.


Clinical findings:
The patient reporting a tick bite presented with fever (38°C), myalgia, abdominal pain, arthralgia, and mild lymphadenopathy in the right axilla. A lesion was observed at the tick-bite site.


Treatment and results:
A biopsy sample was obtained from the tick bite area for diagnosis by PCR and DNA sequencing, yielding 100% homology with the Rickettsia parkeri Atlantic Rainforest strain reported in human cases in Brazil. Treatment consisted of 100mg of doxycycline for 10 days, with symptoms ceasing 24 hours after the start of treatment.


Clinical relevance:
We report the first case of rickettsiosis by Rickettsia parkeri in an urban area in Mexico. Infection is considered mild to moderate, but it is unusual in urban environments. Medics should be concerned about the clinical manifestations associated with tick bites, particularly when lymphadenopathy is present.

Gaspar Fernando Peniche-Lara, Facultad de Medicina de la Universidad Autónoma de Yucatán

orcid_id14.png https://orcid.org/0000-0002-5202-937X

Universidad Autonoma de Yucatan. Merida, Yucatán, México

Karla Dzul-Rosado, Laboratorio de Enfermedades Emergentes y Re-emergentes. Centro de Investigaciones Regionales "Dr. Hideyo Noguchi". Universidad Autónoma de Yucatán. México

orcid_id14.pnghttps://orcid.org/0000-0002-3729-3797  

Associate Researcher Professor with a line of research in the development of DNA vaccines, immunology, and social research related to diseases caused by Rickettsia species in Yucatán, Mexico

Labruna MB, Salim Mattar V, Nava S, et al. Rickettsioses in Latin America, Caribbean, Spain and Portugal. Rev MVZ Cordoba [Internet]. 2011 [cited 2022 Feb 7];16:2435-2457. Available from: https://revistamvz.unicordoba.edu.co/article/view/282. https://doi.org/10.21897/rmvz.282 DOI: https://doi.org/10.21897/rmvz.282

Moo-Llanes DA, de Oca-Aguilar ACM, Romero-Salas D, et al. Inferring the Potential Distribution of an Emerging Rickettsiosis in America: The Case of Rickettsia parkeri. Pathogens [Internet]. 2021 [cited 2022 Feb 7];10. Available from: https://pubmed.ncbi.nlm.nih.gov/34068132/. https://doi.org/10.3390/pathogens10050592 PMid:34068132 PMCid:PMC8152739 DOI: https://doi.org/10.3390/pathogens10050592

Paddock CD, Sumner JW, Comer JA, et al. Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. Clin Infect Dis [Internet]. 2004 [cited 2022 Feb 7];38:805-811. Available from: https://pubmed.ncbi.nlm.nih.gov/14999622/. https://doi.org/10.1086/381894 DOI: https://doi.org/10.1086/381894

PMid:14999622

Silva-Ramos CR, Hidalgo M, Faccini-Martínez ÁA. Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review. Ticks Tick Borne Dis. 2021;12:101734. https://doi.org/10.1016/j.ttbdis.2021.101734 PMid:33989945 DOI: https://doi.org/10.1016/j.ttbdis.2021.101734

Barbieri ARM, Filho JM, Nieri-Bastos FA, et al. Epidemiology of Rickettsia sp. strain Atlantic rainforest in a spotted fever-endemic area of southern Brazil. Ticks Tick Borne Dis. 2014;5:848-853. https://doi.org/10.1016/j.ttbdis.2014.07.010 PMid:25108786 DOI: https://doi.org/10.1016/j.ttbdis.2014.07.010

Nieri-Bastos FA, Horta MC, Barros-Battesti DM, et al. Isolation of the Pathogen Rickettsia sp. Strain Atlantic Rainforest from Its Presumed Tick Vector, Amblyomma ovale (Acari: Ixodidae), from Two Areas of Brazil. J Med Entomol. 2016;53:977-981. https://doi.org/10.1093/jme/tjw062 PMid:27146681 DOI: https://doi.org/10.1093/jme/tjw062

Paddock CD, Allerdice MEJ, Karpathy SE, et al. Unique strain of Rickettsia parkeri associated with the hard tick Dermacentor parumapertus Neumann in the western United States. Appl Environ Microbiol. 2017;83. https://doi.org/10.1128/AEM.03463-16 PMid:28213544 PMCid:PMC5394329 DOI: https://doi.org/10.1128/AEM.03463-16

Nieri-Bastos FA, Marcili A, de Sousa R, et al. Phylogenetic evidence for the existence of multiple strains of Rickettsia parkeri in the New World. Appl Environ Microbiol. 2018;84. https://doi.org/10.1128/AEM.02872-17 PMid:29439989 PMCid:PMC5881050 DOI: https://doi.org/10.1128/AEM.02872-17

Sánchez-Montes S, López-Pérez AM, Guzmán-Cornejo C, et al. Rickettsia parkeri in dermacentor parumapertus ticks, Mexico. Emerg Infect Dis. 2018;24:1108-1111. https://doi.org/10.3201/eid2406.180058 PMid:29774838 PMCid:PMC6004873 DOI: https://doi.org/10.3201/eid2406.180058

Sánchez-Montes S, Colunga-Salas P, Lozano-Sardaneta YN, et al. The genus Rickettsia in Mexico: Current knowledge and perspectives. Ticks Tick Borne Dis. 2021;12. https://doi.org/10.1016/j.ttbdis.2020.101642 PMid:33388557 DOI: https://doi.org/10.1016/j.ttbdis.2020.101642

S S-M, GG B-G, A H-V, et al. Molecular Confirmation of Rickettsia parkeri in Amblyomma ovale Ticks, Veracruz, Mexico. Emerg Infect Dis [Internet]. 2019 [cited 2021 Oct 10];25:2315-2317. Available from: https://pubmed.ncbi.nlm.nih.gov/31742525/. https://doi.org/10.3201/eid2512.190964 PMid:31742525 PMCid:PMC6874242 DOI: https://doi.org/10.3201/eid2512.190964

Torres-Chable OM, Jimenez-Delgadillo BG, Alvarado-Kantún YN, et al. Rickettsia parkeri (Rickettsiales: Rickettsiaceae) detected in Amblyomma maculatum ticks collected on dogs in Tabasco, Mexico. Exp Appl Acarol [Internet]. 2020 [cited 2023 Mar 8];82:431-440. Available from: https://pubmed.ncbi.nlm.nih.gov/33025238/. https://doi.org/10.1007/s10493-020-00524-z PMid:33025238 DOI: https://doi.org/10.1007/s10493-020-00524-z

López-Pérez AM, Sánchez-Montes S, Maya-Badillo BA, et al. Molecular detection of Rickettsia amblyommatis and Rickettsia parkeri in ticks collected from wild pigs in Campeche, Mexico. Ticks Tick Borne Dis [Internet]. 2022 [cited 2023 Mar 8];13. Available from: https://pubmed.ncbi.nlm.nih.gov/34670190/. https://doi.org/10.1016/j.ttbdis.2021.101844 PMid:34670190 DOI: https://doi.org/10.1016/j.ttbdis.2021.101844

Peniche-Lara G, Lara-Perera V. Rickettsiosis Caused by Rickettsia parkeri, Mexico. Emerg Infect Dis [Internet]. 2022 [cited 2022 Feb 7];28:478-479. Available from: https://pubmed.ncbi.nlm.nih.gov/35076372/. https://doi.org/10.3201/eid2802.210454 PMid:35076372 PMCid:PMC8798671 DOI: https://doi.org/10.3201/eid2802.210454

JA O, S N, Rd S, et al. [Latinamerican guidelines of RIICER for diagnosis of tick-borne rickettsioses]. Rev Chilena Infectol [Internet]. 2014 [cited 2021 Oct 9];31:54-65. Available from: https://pubmed.ncbi.nlm.nih.gov/24740776/. https://doi.org/10.4067/S0716-10182014000100009 PMid:24740776 DOI: https://doi.org/10.4067/S0716-10182014000100009

A da PS, TF M, S M-L, et al. A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. Parasit Vectors [Internet]. 2019 [cited 2021 Oct 10];12. Available from: https://pubmed.ncbi.nlm.nih.gov/31604442/. https://doi.org/10.1186/s13071-019-3730-2 PMid:31604442 PMCid:PMC6790035 DOI: https://doi.org/10.1186/s13071-019-3730-2

Torres‐Castro M, Sánchez‐Montes S, Colunga‐Salas P, et al. Molecular confirmation of Rickettsia parkeri in humans from Southern Mexico. Zoonoses Public Health [Internet]. 2022 [cited 2022 Feb 20]; Available from: https://pubmed.ncbi.nlm.nih.gov/35142079/.

Abarca K, Oteo JA. [Clinical approach and main tick-borne rickettsiosis present in Latin America]. Rev Chilena Infectol [Internet]. 2014 [cited 2022 Nov 21];31:569-576. Available from: https://pubmed.ncbi.nlm.nih.gov/25491456/. https://doi.org/10.4067/S0716-10182014000500009 PMid:25491456 DOI: https://doi.org/10.4067/S0716-10182014000500009

Fournier PE, Dumler JS, Greub G, et al. Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol [Internet]. 2003 [cited 2022 Feb 16];41:5456-5465. Available from: https://pubmed.ncbi.nlm.nih.gov/14662925/. https://doi.org/10.1128/JCM.41.12.5456-5465.2003 PMid:14662925 PMCid:PMC308961 DOI: https://doi.org/10.1128/JCM.41.12.5456-5465.2003

Hidalgo M, Faccini-Martínez álvaro A, Valbuena G. Rickettsiosis transmitidas por garrapatas en las Américas: Avances clínicos y epidemiológicos, y retos en el diagnóstico. Biomedica. 2013;33:161-178. https://doi.org/10.7705/biomedica.v33i0.1466 DOI: https://doi.org/10.7705/biomedica.v33i0.1466

Panti-May J, Panti-May JA, Torres-Castro MA, et al. ZOONOTIC PARASITES AND MICROMAMMALS IN THE YUCATAN PENINSULA, MEXICO: CONTRIBUTIONS OF THE CCBA-UADY. Tropical and Subtropical Agroecosystems [Internet]. 2021 [cited 2022 Feb 16];24. Available from: https://www.revista.ccba.uady.mx/ojs/index.php/TSA/article/view/3343. https://doi.org/10.56369/tsaes.3343 DOI: https://doi.org/10.56369/tsaes.3343

Scott AT, Vondrak CJ, Sanderlin AG, et al. Rickettsia parkeri. Trends Microbiol [Internet]. 2022 [cited 2022 Feb 20]; Available from: https://pubmed.ncbi.nlm.nih.gov/35115187/.

Armitano RI, Guillemi E, Escalada V, et al. [Spotted fever in Argentina. Description of two clinical cases]. Rev Argent Microbiol [Internet]. 2019 [cited 2022 Feb 16];51:339-344. Available from: https://pubmed.ncbi.nlm.nih.gov/30928146/. https://doi.org/10.1016/j.ram.2018.11.001 PMid:30928146 DOI: https://doi.org/10.1016/j.ram.2018.11.001

Dzul-Rosado KR, Reyes-Novelo E, Lugo-Caballero C, et al. Urban ecology of hosts and vectors of Rickettsia in a rickettsiosis-endemic city of the Yucatan peninsula, Mexico. Acta Trop. 2021;216. https://doi.org/10.1016/j.actatropica.2021.105832 PMid:33465349 DOI: https://doi.org/10.1016/j.actatropica.2021.105832

Peniche-Lara, G. F., & Dzul-Rosado, K. (2025). First Urban Case of Rickettsia parkeri (Atlantic Rainforest Strain) Rickettsiosis in Mérida, Mexico: A Case Report. Colombia Medica, 56(3), e5005779. https://doi.org/10.25100/cm.v56i3.5779

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Received 2023-09-19
Accepted 2025-10-21
Published 2025-09-30