Serum Interleukin-36γ Levels in Children with Allergic Rhinitis A Cross-Sectional Study
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Objectives:
This study aimed to investigate whether serum Interleukin 36 gamma (IL-36γ) levels in pediatric allergic rhinitis patients correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36γ as a biomarker and its role in disease pathogenesis to inform future treatment strategies.
Methods:
In this cross-sectional observational study, pediatric allergic rhinitis patients from outpatient clinics were compared with healthy controls. Serum IL-36γ levels were measured from blood samples and analyzed across subgroups based on disease severity and duration.
Results:
Fifty patients with allergic rhinitis and forty controls were included. IL-36γ levels were higher in the patient group with borderline significance (p= 0.050). Female patients had significantly higher IL-36γ levels than male controls (p= 0.044).
Conclusions:
This is the first study to evaluate IL-36γ levels in pediatric allergic rhinitis. Although the difference between groups showed borderline significance, larger studies may confirm these findings. The observed gender-related difference suggests IL-36γ could be a potential biomarker. Additionally, a significant negative correlation with total IgE and a nonsignificant negative correlation with eosinophil counts were noted.
- cytokines
- pediatric allergy
- allergic rhinitis
- Interleukin 36 gamma
- Immunoglobulin E
- Rhinitis, Allergic
- Cell Degranulation
- Th2 Cells
- Interleukin-1
Dogukan Aydenizoz, University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey
0000-0003-4012-3841
University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey
Omer Tarik Selcuk, University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey
University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey
Hulya Eyigor, Health Sciences University Antalya Training and Research Hospital Otorhinolaryngology Dept
0000-0001-5317-431X
University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey
Hamit Yasar Ellidag, University of Health Sciences, Antalya Training and Research Hospital, Department of Biochemistry, Antalya, Turkey
0000-0002-7511-2547
University of Health Sciences, Antalya Training and Research Hospital, Department of Biochemistry, Antalya, Turkey
Serkan Filiz, University of Health Sciences, Antalya Training and Research Hospital, Department of Pediatric Allergy and Immunology, Antalya, Turkey
0000-0002-7733-9067
University of Health Sciences, Antalya Training and Research Hospital, Department of Pediatric Allergy and Immunology, Antalya, Turkey
Sennur Keles, University of Health Sciences, Antalya Training and Research Hospital, Department of Pediatric Allergy and Immunology, Antalya, Turkey
0000-0001-8282-190X
University of Health Sciences, Antalya Training and Research Hospital, Department of Pediatric Allergy and Immunology, Antalya, Turkey
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Accepted 2025-09-09
Published 2025-06-30
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