Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model.
Abstract
Introduction: There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration.Objective: To determine the anti-secretory effect of the species Cannabis sativa.
Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH.
Results: The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes.
Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.
Authors
Downloads
Download data is not yet available.
Keywords
- Cannabis
- Gastric juice
- Cannabinoids
- Tetrahydrocannabinol
Submitted
2009-11-20
|
418 |
How to Cite
Castillo, G. G., Pachajoa, H. M., Villota, S. E., Zurita, E., Palacios, M., & Gutiérrez, O. (1). Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model. Colombia Médica, 37(4), 254-257. https://doi.org/10.25100/cm.v37i4.454
Issue
Section
Original Articles
The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use