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  1. Home /
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  3. Vol 39 No 3 Supl 3 (2008): Neurociencias /
  4. Original Articles

Effectiveness of ivermectin in rats with haloperidol induced tardive dyskinesia.

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Abstract

Introduction: Extrapiramidal symptoms and tardive dyskinesia are common problems associated with antypsychotic therapy. Basic and clinical research is warranted due to the lack of effective therapies aimed to the prevention and treatment of antipsychotic side effects.
Objective: To evaluate the effect of ivermectin in rats with haloperidol induced tardive dyskinesia.
Methods: The effect of ivermectin on motor behavior and abnormal movements was tested in Sprague-Dawley rats treated with a single dose of haloperidol. In addition, a chronic animal model known as VCM (vacuous chewing movements) was implemented with the objective to evaluate the effect of ivermectin on the frequency of orofacial movements during a period of six months.
Results: Ivermectin does not prevent the motor behavior and frequency of abnormal movements induced by haloperidol in the acute model. Orofacial movements were not reduced with ivermectin in the chronic model. In addition, ivermectin was not associated with changes in motor behavior and abnormal movements in the acute and chronic model.
Conclusions: Ivermectin is not a good candidate for the treatment of tardive dyskinesia and the results of this study do not support the GABAergic hypothesis in the physiopathology of tardive dyskinesia. Additionally, ivermectin does not induce abnormal movements.

Authors

  • Mauricio Palacios Universidad del Valle
  • Hernán Pimienta Universidad del Valle

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Keywords

  • Haloperidol
  • Ivermectin
  • Dyskinesia drug induced
  • Antipsychotic agents

Author Biography


, Universidad del Valle
Profesor Distinguido, Director Centro de Estudios Cerebrales, Facultad de Salud, Universidad del Valle, Cali, Colombia.
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Submitted
2009-12-01
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How to Cite
Palacios, M., & Pimienta, H. (1). Effectiveness of ivermectin in rats with haloperidol induced tardive dyskinesia. Colombia Médica, 39(3 Supl 3), 71-77. https://doi.org/10.25100/cm.v39i3Supl3.608
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Issue
Vol 39 No 3 Supl 3 (2008): Neurociencias
Section
Original Articles

The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use

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