Abdominal actinomycosis by Actinomyces shaaliae georgiae mimicking neoplasia Case report

Abstract

Objective
This study aimed to investigate whether serum Interleukin 36 gamma (IL-36γ) levels in pediatric patients with allergic rhinitis correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36γ as a biomarker and its role in disease pathogenesis to inform future treatment strategies.

Methods
In this cross-sectional observational study, pediatric patients with allergic rhinitis from outpatient clinics were compared with healthy controls. Serum IL-36γ levels were measured from blood samples and analyzed across subgroups based on disease severity and duration.

Results
Fifty patients with allergic rhinitis and forty controls were included. IL-36γ levels were higher in the patient group, with borderline significance (p = 0.050). Female patients had significantly higher IL-36γ levels than male controls (p= 0.044).

Conclusion
This is the first study to evaluate IL-36γ levels in pediatric allergic rhinitis. Although the difference between groups showed borderline significance, larger studies may confirm these findings. The observed gender-related difference suggests IL-36γ could be a potential biomarker. Additionally, a significant negative correlation with total IgE and a nonsignificant negative correlation with eosinophil counts were noted.