Authors Response: Tuberculosis and pulmonary candidiasis co-infection present in a previously healthy patient
In response to the note about the case described 1, we fully agree that immunodeficiency is not only the relationship with HIV infection, and that there are pathologies and different immunological and genetic conditions associated with it 2-4; the main ones were discarded in the patient.
In the patient of the presented clinical case, there is no family history of primary immunodeficiencies. And in her personal history, there were not found any data related to recurrent infectious processes, either in childhood or present, which does not lead to suspicion of diseases with primary immunodeficiencies, in which recurrent infections would be expected as in the case of recurrent pneumonia, lung, spleen and liver abscesses, cervical, axillary and inguinal lymphadenitis, or bone and skin infections, as in the case of chronic granulomatous disease 5.
For other primary immunodeficiencies provided by the reader, such as the case of X-linked agammaglobulinemia, this is a congenital disease that affects males and involves B lymphocytes and plasma cells, which are not the primary immune line in tuberculosis6, nor does it correspond to our case.
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