Case report: Multifocal chronic paracoccidioidomycosis in an adult

https://doi.org/10.25100/cm.v42i2.776

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Published: Jul 23, 2024
Updated: 2024-07-23
Versions:
2024-07-23 (2)
Issue: Vol. 42 No. 2 (2011)
Section Case Report

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Authors

Karen Zapata
Janeth Villanueva
Adriana Arrunátegui
Juana Gabriela López
Abstract
Paracoccidioides brasiliensis is the ethiological agent of one of the most prevalent systemic mycosis in Latin America, where around ten-million individuals are affected. Brazil has the highest incidence but in Venezuela, Colombia, Ecuador, and Argentina cases have also been reported. We describe a 56-year-old male with a one year history of lip, oral mucosa, and lung lesions. Granulomas and multinucleated giant cells were observed in histopathological evaluation with haematoxilyn-eosin stain. Mycologic studies (KOH and Gomori Grocott stain) showed blastoconidias with multiple budding. Serologic tests for paracoccidioidine were reactive. A diagnosis of chronic multifocal paracoccidioidomycosis was made. Initially, amphotericin B 0.7 mg/kg per day was started for fifteen days and consecutively itraconazole (400 mg/day) was administered orally with improvement of skin and lung lesions; however, an important residual fibrosis was observed. The patient was lost to follow up. We highlight the importance of an early diagnosis and adequate treatment to decrease sequelae in patient quality of life.
Keywords
  • Paracoccidioidomycosis
  • Paracoccidioides brasiliensis
  • Diagnosis
  • Amphotericin B
  • Itraconazole
  • Complications
References

Arenas R. Micología médica ilustrada. 3ª ed. México, DF:Interamericana, McGraw-Hill; 2008.2.Ramos e Silva M, Do Espirito Santo Saraiva L. Paraco-ccidioidomycosis. Dermatol Clin. 2008; 26: 257-69.3.Poisson DM, Heitzmann A, Mille C, Muckensturm B, DromerF, Dupont B, et al.Paracoccidioides brasiliensis in a brainabscess: first french case. J Mycol Med. 2007; 17: 114-8.4.Bagagli E, Bosco S, Cordeiro R, Franco M. Phylogenetic andevolutionary aspects of Paracoccidioides brasiliensis reveal along coexistence with animal host that explain several biologicalfeatures of the pathogen. Infect Genet Evol. 2006; 6: 344-51.5.Almeida AJ, Martins M, Carmona JA, Cano LE, Restrepo A,Leao C, et al. New insight into the cell cycle profile ofParacoccidioides brasiliensis. Fungal Genet Biol. 2006; 43:401-9.6.Torrado E, Castañeda E, De La Hoz F, Restrepo A.Paracoccidioidomicosis: definición de las áreas endémicas enColombia. Biomedica. 2000; 20: 327-34.7.Lyon A, Teixeira M, Araújo S, Pereira M, Pedroso E, TeixeiraA. Serum levels of sTNF-R1, sTNF-R2 and CXCL9 correlatewith disease activity in adult type paracoccidioidomycosis.Acta Trop. 2009; 109: 213-8.8.Simao M. Paracoccidioidomycosis. Paediatr Respir Rev. 2009;10: 161-5.9.Menezes VM, Soares BGO, Fontes CJF. Drugs for treatingparacoccydioidomycosis. Cochrane database of systematicreviews. 2006; 2. N° CD004967. DOI: 10.1002/14651858.CD004967.pub2 DOI: https://doi.org/10.1002/14651858.CD004967.pub2

How to Cite
Zapata, K., Villanueva, J., Arrunátegui, A., & López, J. G. (2024). Case report: Multifocal chronic paracoccidioidomycosis in an adult. Colombia Medica, 42(2), 228–232. https://doi.org/10.25100/cm.v42i2.776 (Original work published June 14, 2011)
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