NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
Main Article Content
Objective: To study the NAT2 gene polymorphisms 481T, 590A, and 857A in the Chimila, Wiwa, and Wayuu Indigenous groups of the Colombian Caribbean to determine the frequencies of the allelesNAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylation present in these populations.
- NAT2
- single nucleotide polymorphism
- genotyping
- acetylation
- Isoniazid
- Chimila
- Wiwa
- Wayuu
- Indigenous groups
Fuselli S, Gilman RH, Chanock SJ, Bonatto SL, De Stefano G, Evans CA, et al. Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across native American populations and high intra-population diversity. Pharmacogenomics J. 2007; 7: 144–52. DOI: https://doi.org/10.1038/sj.tpj.6500407
Walraven JM, Zang Y, Trent JO, Hein DW. Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2. Curr Drug Metab. 2008; 9(6): 471–86. DOI: https://doi.org/10.2174/138920008784892065
Dupret JM, Rodríguez-Lima F. Structure and Regulation of the Drug-Metabolizing Enzymes Arylamine N-Acetyltransferases. Curr Med Chem. 2005; 12(3): 311–8. DOI: https://doi.org/10.2174/0929867053363289
Butcher NJ, Boukouvala S, Sim E, Minchin RF. Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics J. 2002; 2(1): 30–42. DOI: https://doi.org/10.1038/sj.tpj.6500053
Walker K, Ginsberg G, Hattis D, Johns DO, Guyton KZ, Sonawane B. Genetic polymorphism in N-acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity. J Toxicol Environ Health B Crit Rev. 2009; 12(5-6): 440–72. DOI: https://doi.org/10.1080/10937400903158383
Doll MA, Fretland AJ, Deitz AC, Hein DW. Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification. Anal Biochem. 1995; 231(2): 413–20. DOI: https://doi.org/10.1006/abio.1995.9978
Human NAT2 Alleles (Haplotypes). Database of arylamine N-Acetyltransferases (NATs). Accessed: November 14 2013. Available from: http://nat.mbg.duth.gr/Human%20NAT2%20alleles_2013.htm.
García-Martín E. Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr Drug Metab. 2008; 9(6): 487–97. DOI: https://doi.org/10.2174/138920008784892155
Boukouvala S, Fakis G. Arylamine N-acetyltransferases: What we learn from genes and genomes. Drug Metab Rev. 2005; 37(3): 511–64. DOI: https://doi.org/10.1080/03602530500251204
Bailliet G, Santos MR, Alfaro EL, Dipierri JE, Demarchi DA, Carnese FR, et al. Allele and genotype frequencies of metabolic genes in native Americans from Argentina and Paraguay. Mutat Res. 2007; 627: 171–7. DOI: https://doi.org/10.1016/j.mrgentox.2006.11.005
Jorge-Nebert LF, Eichelbaum M, Griese EU, Inaba T, Arias T. D. Analysis of six SNPs of NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera acetylation phenotype using caffeine. Pharmacogenetics. 2002; 12(1): 39–48. DOI: https://doi.org/10.1097/00008571-200201000-00006
Talbot J, Magno LA, Santana CV, Sousa SM, Melo PR, Correa RX, et al. Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations. BMC Genet. 2010; 11: 87. DOI: https://doi.org/10.1186/1471-2156-11-87
Consejeria Presidencial para los derechos Humanos. Diagnóstico de la situación del pueblo indígena Chimila-Ette Ennaka. Accessed: November 14 2013. Available from: http://www.derechoshumanos.gov.co/Observatorio/documents/2010/DiagnosticoIndigenas/Diagnostico_CHIMILA.pdf.
Uribe TCA. Introducción a la Colombia Amerindia-Chimila. Instituto Colombiano de Antropología; Bogotá: 1987. Accessed: November 14 2013. Available from: http://www.banrepcultural.org/blaavirtual/antropologia/amerindi/chimila.htm.
ACNUR. Descripción general de los pueblos Indígenas de Colombia. Accessed: February 24 2013. Available from: http://www.acnur.org/biblioteca/pdf/4435.pdf?view=1. 298-397. ONU.
UNHCR, ACNUR. Comunidades indígenas. Accessed: February 24 2013. Available from: http://www.acnur.org/t3/fileadmin/Documentos/Pueblos_indigenas/2011/Comunidades_indigenas_en_Colombia_-_ACNUR_2011.pdf?view=1. ONU.
Consejeria Presidencial para los derechos Humanos. Diagnóstico de la situación del pueblo indígena Wiwa. Accessed: November 14 2013. Available from: http://www.derechoshumanos.gov.co/Observatorio/documents/2010/DiagnosticoIndigenas/Diagnostico_WIWA.pdf.
Consejeria Presidencial para los derechos Humanos. Diagnóstico de la situación del pueblo indígena Wayuu. Accessed: November 14 2013. Available from: http://www.derechoshumanos.gov.co/Observatorio/documents/2010/DiagnosticoIndigenas/Diagnostico_WAY%C3%9AU.pdf.
Life Technologies. SNP genotyping analysis using TaqMan(r) assays. Accessed: February 8 2011. Available from: http://www.lifetechnologies.com/co/en/home/life-science/pcr/real-time-pcr/real-time-pcr-assays/snp-genotyping-taqman-assays.html.
Torkaman-Boutorabi A, Hoormand M, Naghdi N, Bakhshayesh M, Milanian I. Genotype and allele frequencies of N-acetyltransferase 2 and glutathione S-transferase in the Iranian population. Clin Exp Pharmacol Physiol. 2007; 34: 1207–11. DOI: https://doi.org/10.1111/j.1440-1681.2007.04753.x
Hamdy SI, Hiratsuka M, Narahara K, Endo N, El-Enany M, Moursi N, et al. Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population. Br J Clin Pharmacol. 2003; 55: 560–9. DOI: https://doi.org/10.1046/j.1365-2125.2003.01786.x
Kubota R, Ohno M, Hasunuma T, Iijima H, Azuma J. Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2. Eur J Clin Pharmacol. 2007; 63: 927–33. DOI: https://doi.org/10.1007/s00228-007-0333-1
Hiratsuka M, Kishikawa Y, Takekuma Y, Matsuura M, Narahara K, Inoue T, et al. Genotyping of N-acetyltransferase2 polymorphism in the prediction of adverse drugs reactions to isoniazid in Japanese patients. Drug Metab Pharmacokinet. 2002; 17(4): 357–62. DOI: https://doi.org/10.2133/dmpk.17.357
Chen B, Cai W, Li J, Cao X. Estimating N-acetyltransferase metabolic activity and pharmacokinetic parameters of isoniazid from genotypes in Chinese subjects. Clin Chim Acta. 2009; 405: 23–9. DOI: https://doi.org/10.1016/j.cca.2009.03.045
Downloads

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use