Main Article Content

Objective:

To analyze if there is an association between the presence of polymorphisms in the LPL gene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population.

Methods:

In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ray CT) and 269 subjects without stroke as controls were studied. PCR -RFLP technique was used to detect rs320, rs285 and rs328 polymorphisms in the LPL gene.

Results:

In the present research was not found any association between any of the LPL gene polymorphism and acute ischemic stroke in the population studied; the allele and genotypic frequencies of the studied polymorphisms were similar in cases and controls and followed the Hardy-Weinberg equilibrium. The study was approved by the IRB and each subject signed the informed consent.

Conclusion:

LPL gene polymorphisms are not genetic markers for the development of stroke in the Colombian sample used.

Leydi Carolina Velásquez Pereira, Universidad Industrial de Santander, Bucaramenga, Colombia.

Departamento de ciencias básicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramenga, Colombia

Clara Inés Vargas Castellanos, Universidad Industrial de Santander, Bucaramenga, Colombia.

Departamento de ciencias básicas, Facultad de Salud, Universidad Industrial de Santander, Bucaramenga, Colombia

Federico Arturo Silva Sieger, Fundación Cardiovascular de Colombia, Bucaramanga, Colombia.

Grupo de Ciencias Neurovasculares. Fundación Cardiovascular de Colombia, Bucaramanga, Colombia.
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Received 2014-08-25
Accepted 2016-11-06
Published 2016-12-21