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Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials.

Alvaro Barrera-Ocampo, Universidad Icesi , Cali, Colombia.

Departamento de Ciencias Farmacéuticas , Grupo de Investigación Natura, Facultad de Ciencias Naturales , Universidad Icesi , Cali, Colombia.

Francisco Lopera, Universidad de Antioquia, Medellin, Colombia.

Grupo de Neurociencias de Antioquia , Escuela de Medicina, Universidad de Antioquia, Medellin, Colombia.
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Received 2016-11-10
Accepted 2017-01-02
Published 2024-06-11