Main Article Content

Authors


  • Introduction: Several studies have reported that the single nucleotide polymorphism rs693 of Apo lipoprotein B gene is associated with high levels of plasma lipids and high body mass index, which are risk factors for cardiovascular diseases. The distribution of this single nucleotide polymorphism and its association with the phenotype depend on the genetic background of each population.

  •  Objective: To evaluate the distribution of single nucleotide polymorphism rs693 and its association with lipid profile and body mass index in a sample of Colombian Caribbeans.

  •  Methods108 non-related adult subjects of both gender were included in this study. Body mass index and lipid profile that included total cholesterol, triglycerides, Low Density Lipoprotein and High Density Lipoprotein were determined. The single nucleotide polymorphism rs693 was determined by Polymerase Chain Reaction/Restriction Fragment Length Polymorphism from genomic DNA followed by digestion with the restriction enzyme XbaI. The chi-square test was used to analyze the genotype distribution of rs693 and the genotype-phenotype association was evaluated through different inheritance model.

  •  ResultsThe genotype frequencies for single nucleotide polymorphism rs693 were CC (45.0%), TT (16.5%) and CT (38.5%). The allele frequencies were C (64.0%) and T (36.0%). The single nucleotide polymorphism was in Hardy-Weinberg equilibrium in the studied sample. No association of the single nucleotide polymorphism rs693 with lipid profile nor the body mass index was found (p >0.05).



  • Conclusion: There is no significant association between single nucleotide polymorphism rs693 and body mass index nor lipid profile, in a sample of Colombian Caribbeans.

Evelyn Mendoza-Torres, Professor and Researcher. Faculty of Health Sciences. Universidad Libre, Barranquilla-Colombia.

Universidad Libre, Grupo de Investigación Avanzada en Biomedicina, Barranquilla, Colombia

AAA_orcid_id.png https://orcid.org/0000-0002-4586-3753

Nicole Samuel Pereira Sanandrés, Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

AAA_orcid_id1.png https://orcid.org/0000-0001-7431-4967

José Luis Villarreal Camacho, 1.Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.2. Universidad del Norte, Barranquilla, Colombia.

1-Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

2 Universidad del Norte, Barranquilla, Colombia.

AAA_orcid_id2.png https://orcid.org/0000-0002-7240-7462

 

Xilene Mendoza, 1-Universidad Metropolitana, Grupo de Investigación en Medicina Traslacional (GIMET), Barranquilla, Colombia. 2- Corporación Universitaria Rafael Núñez, Programa de Enfermería, Barranquilla, Colombia.

1-Universidad Metropolitana, Grupo de Investigación en Medicina Traslacional (GIMET), Barranquilla, Colombia.

2- Corporación Universitaria Rafael Núñez, Programa de Enfermería, Barranquilla, Colombia.

AAA_orcid_id3.png https://orcid.org/0000-0003-3589-1547

César De La Espriella, Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

AAA_orcid_id4.png https://orcid.org/0000-0001-5270-2838

Lourdes Luz Varela Prieto, Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia.

AAA_orcid_id5.png https://orcid.org/0000-0001-6000-3113

Daniel Antonio VillanuevaTorregosa, Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia

Universidad Libre, Grupo de Investigación en Bioquímica Patológica (GRUBIOPAT). Barranquilla, Colombia

AAA_orcid_id6.png https://orcid.org/0000-0003-4018-146X

Mendoza-Torres, E., Pereira Sanandrés, N. S., Villarreal Camacho, J. L., Mendoza, X., De La Espriella, C., Varela Prieto, L. L., & VillanuevaTorregosa, D. A. (2024). Distribution of polymorphism rs693 of ApoB gene in a sample of Colombian Caribbeans. Colombia Medica, 50(3), 153–162. https://doi.org/10.25100/cm.v50i3.4048

Downloads

Download data is not yet available.
Received 2019-11-27
Accepted 2019-12-13
Published 2024-05-22

Similar Articles

  • José Pacheco-Romero, Oscar Acosta Conchucos, Doris Huerta Canales, Santiago Cabrera Ramos, Marlene Vargas Chávez, Pedro Mascaro Sánchez, Moisés Huamán Guerrero, José Sandoval Paredes, Rudy López Gabriel, Julio Mateus, Enrique Gil Guevara, Enrique Guevara Ríos, Nitza Butrica Ferré, Diana Catari Soto, David Bellido Yarlequé, Gina Custodio Gonzales, Andrea Naranjo Andonaire, Genetic markers for preeclampsia in Peruvian women , Colombia Medica: Vol. 52 No. 1 (2021)

You may also start an advanced similarity search for this article.