COVID-19 and the Heart
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) has resulted in a global health crisis. Prior to the arrival of this viral pandemic, the world was already plagued with a significant burden of cardiovascular disease. With the introduction of the novel virus, the world now faces a double jeapordy. Early reports have suggested an increased risk of death in individuals with underlying cardio-metabolic disorders. The exact effects of COVID-19 on the cardiovascular system are not well determined, however lessons from prior viral epidemics suggest that such infections can trigger acute coronary syndromes, arrhythmias and heart failure via direct and indirect mechanisms. In this article, we aimed to discuss the effects and potential underlying mechanisms of COVID -19 as well as potential implications of treatments targeted against this virus on the cardiovascular system.
- Aged
- COVID-19
- angiotensin converting enzyme 2
- Peptidyl-Dipeptidase A
- Coronary Artery Disease
- Troponin I
- Angiotensin-Converting Enzyme Inhibitors
- Coronavirus
- American Heart Association
- Plaque, Atherosclerotic
- Atrial Fibrillation
- Myocarditis
- Cardiovascular Diseases
- Acute Coronary Syndrome
Chaitanya Rojulpote, University of Pennsylvania, Departments of Medicine and Radiology, Philadelphia, USA, 2 The Wright Center for Graduate Medical Education, Department of Internal Medicine, Scranton, United States
https://orcid.org/0000-0002-7457-9014Karthik Gonuguntla, University of Connecticut, University of Connecticut, Department of Internal Medicine, Philadelphia, USA,
University of Connecticut, Department of Internal Medicine, Philadelphia, United States
Shivaraj Patil, University of Connecticut, University of Connecticut, Department of Internal Medicine, Philadelphia, USA,
University of Connecticut, University of Connecticut, Department of Internal Medicine, Philadelphia, USA
Abhijit Bhattaru, University of Pennsylvania, Departments of Medicine and Radiology, Philadelphia, USA,
University of Pennsylvania, Departments of Medicine and Radiology, Philadelphia, USA
Paco Bravo, Faculty - Division of Nuclear Medicine, Department of Radiology; Division of Cardiology, Department of Medicine, University of Pennsylvania
Department: Radiology
Education: MD (Doctor Of Medicine) Universidad Del Valle, 2002.
https://orcid.org/0000-0002-0022-4376Description of Clinical Expertise
Cardiac PET, myocardial blood flow quantification in ischemic and non-ischemic heart disease, myocardial inflammation, myocardial viability, cardiac magnetic resonance imaging, cardiomyopathies.
I have a particular interest in the complementary role of radionuclide molecular imaging techniques and tissue characterization with contrast-enhanced cardiac magnetic resonance imaging for sub-clinical detection, phenotyping, diagnosis, and risk stratification of individuals with various forms of cardiomyopathy.
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