Antibody deficiencies with normal IgG in adults with Non-cystic fibrosis bronchiectasis or recurrent pneumonia: Cross-sectional study
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Background
Inborn errors of immunity, mainly Predominantly Antibody deficiencies with normal IgG levels, are unrecognized in adults with lung diseases such as bronchiectasis or recurrent pneumonia.
Objective
To determine IgM, IgA, IgG2 subclass deficiencies, and Specific antibody deficiency (anti-pneumococcal polysaccharide antibodies) in adults with non-cystic fibrosis bronchiectasis or recurrent pneumonia.
Methods
Cross-sectional study. Consecutive patients with non-cystic fibrosis bronchiectasis or recurrent pneumonia were recruited in Cali, Colombia. IgG, IgA, IgM; IgE, IgG2 subclass, and IgG anti-pneumococcal serum levels were measured.
Results
Among the 110 participants enrolled, Antibody deficiencies with normal serum IgG levels were found in 11(10%) cases. IgA deficiency (3 cases), IgM deficiency (2 cases), and IgG2 deficiency (2 cases) were the most frequent primary immunodeficiencies. In addition, IgG2+IgA deficiency, Ataxia-telangiectasia, Hyper-IgE syndrome and Specific Antibody Deficiency(anti-polysaccharides) were found in one case each.
Conclusions
Predominantly antibody deficiencies with normal IgG levels are an important etiology of non-cystic fibrosis bronchiectasis and recurrent pneumonia in adults.
- bronchiectasis
- recurrent pneumonia
- predominantly antibody deficiencies
- Ig G2 subclass deficiency
- specific antibody deficiency
- anti-polysaccharides antibodies
Andres F Zea-Vera, Universidad del Valle, Escuela de Ciencias Básicas, Departamento de Microbiología, Grupo de investigación VIREM, Cali, Colombia
https://orcid.org/0000-0001-9127-3677
Mario Alejandro Chacón, MD, Universidad del Valle, Escuela de Ciencias Básicas, Departamento de Microbiología, Grupo de investigación VIREM, Cali, Colombia
https://orcid.org/0000-0001-6736-3015
Beatriz Parra, Universidad del Valle, Escuela de Ciencias Básicas, Departamento de Microbiología, Grupo de investigación VIREM, Cali, Colombia
https://orcid.org/0000-0002-5371-7449
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