Perıostın and fıbronectın ın nasal lesıons: key players ın polyps and ınverted papıllomas
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Background
Sinonasal lesions are common benign masses with overlapping clinical and histopathological features. Extracellular matrix proteins such as periostin, fibronectin, and tenascin-C play key roles in tissue remodeling and inflammation, yet their distinct expression profiles in these lesions remain poorly defined.
Aim
This study aimed to compare the immunohistochemical staining patterns of periostin, fibronectin, and tenascin-C in sinonasal lesions to elucidate their roles in pathogenesis and enhance differential diagnosis.
Methods
In this retrospective study, pathological specimens from 70 patients who underwent surgery for sinonasal polyps were analyzed. Using a semi-quantitative scoring system, the immunohistochemical expression of periostin, fibronectin, and tenascin-C was assessed separately in epithelial and stromal compartments. Multinomial logistic regression analysis evaluated associations between staining patterns and lesion types.
Results
The study cohort had a male-to-female ratio of 5:2 with a mean age of approximately 40. Nasal polyps demonstrated significantly higher stromal periostin staining than antrochoanal polyps and inverted papillomas. Conversely, antrochoanal polyps exhibited significantly elevated epithelial periostin expression relative to inverted papillomas. Fibronectin expression was markedly increased in nasal polyps, particularly within the stroma, supporting its role in inflammatory tissue remodeling. In contrast, tenascin-C did not display significant differences among the lesion types.
Conclusion
The differential expression of periostin and fibronectin in sinonasal lesions underscores distinct pathogenic mechanisms that may aid in more accurate diagnosis. The compartment-specific staining patterns of periostin and the prominent fibronectin expression in nasal polyps suggest these biomarkers could serve as valuable diagnostic tools and potential therapeutic targets. Future studies should further explore these pathways to develop targeted interventions for sinonasal diseases.
- Antrochoanal polyp
- Inverted papilloma,
- Periostin
- Nasal Polyps
- Tenascin
- Fibronectins
- Integrins
Mehmet Birinci, a:1:{s:5:"en_US";s:100:"Recep Tayyip Erdogan University Faculty of Medicine
https://orcid.org/0000-0001-8184-7454
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
Oğuzhan Okçu, Recep Tayyip Erdogan University Faculty of Medicine, Department of Pathology, Rize, Turkey
https://orcid.org/0000-0001-7481-4718
Recep Tayyip Erdogan University Faculty of Medicine, Department of Pathology, Rize, Turkey
Tuğba Yemiş, Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
https://orcid.org/0000-0001-8713-0251
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
Oğuz Gül, Akçaabat Haçkalı Baba State Hospital, Department of Otorhinolaryngology, Trabzon, Turkey
https://orcid.org/0009-0005-5959-8937
Akçaabat Haçkalı Baba State Hospital, Department of Otorhinolaryngology, Trabzon, Turkey
Suat Terzi, Avrasya University
https://orcid.org/0000-0002-1131-3649
Avrasya University, Avrasya University, Faculty of Health Science, Department of Audiology, Trabzon , Turkey
Metin Çeliker, Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
https://orcid.org/0000-0002-9833-402X
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
Özlem Çelebi Erdivanlı, Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
https://orcid.org/0000-0001-9245-1551
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Otorhinolaryngology, Rize, Turkey
Tolga Mercantepe, Recep Tayyip Erdogan University Faculty of Medicine
https://orcid.org/0000-0002-8506-1755
Recep Tayyip Erdogan University Faculty of Medicine, Department of Histology and Embryology, Rize, Turkey
Levent Tümkaya, Ondokuz Mayıs University Faculty of Medicine, Department of Histology and Embryology, Samsun, Turkey
https://orcid.org/0000-0002-2814-5194
Ondokuz Mayıs University Faculty of Medicine, Department of Histology and Embryology, Samsun, Turkey
Başar Erdivanlı, Recep Tayyip Erdogan University Faculty of Medicine, Department of Anesthesiology and Reanimation, Rize, Turkey
https://orcid.org/0000-0002-3955-8242
Recep Tayyip Erdogan University Faculty of Medicine, Department of Anesthesiology and Reanimation, Rize, Turkey
Engin Dursun, Lokman Hekim University, Faculty of Medicine, Department of Otorhinolaryngology, Ankara, Turkey
https://orcid.org/0000-0002-2070-8677
Lokman Hekim University, Faculty of Medicine, Department of Otorhinolaryngology, Ankara, Turkey
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