Main Article Content
Objective: Genotyping the C/T-13910 and G/A-22018 polymorphisms in a sample of Colombian Caribbean individuals.
Materials and methods: The polymorphisms were identified through Polymerase Chain Reaction/Restriction Fragment Length Polymorphism. Amplified fragments were digested using Hinf I and Hha I. Arlequin v. 3.1 was used to determine allelic and genotypic frequencies, Hardy Weinberg equilibrium, and linkage disequilibrium.
Results: Genotypic frequencies were CC (81.4%), CT (18.6%), and TT (0%) for the C/T-13910 polymorphism. Frequencies were AA (55.5%), GA (45.5%), and GG (0%) for the G/A-22018 polymorphism. No linkage disequilibrium was found between the two loci. Only the locus containing the C/T-13910 polymorphism was found in Hardy Weinberg equilibrium.
Conclusion: The allelic and genotypic distributions observed in this first genotyping study in a Colombian Caribbean population indicate a distribution pattern different from the one of the North European Caucasians and do not correspond to the lactase persistence prevalence reported for Caribbean populations.
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