Global differential expression of genes located in the Down Syndrome Critical Region in normal human brain
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Background:
The information of gene expression obtained from databases, have made possible the extraction and analysis of data related with several molecular processes involving not only in brain homeostasis but its disruption in some neuropathologies; principally in Down syndrome and the Alzheimer disease.
Objective:
To correlate the levels of transcription of 19 genes located in the Down Syndrome Critical Region (DSCR) with their expression in several substructures of normal human brain.
Methods:
There were obtained expression profiles of 19 DSCR genes in 42 brain substructures, from gene expression values available at the database of the human brain of the Brain Atlas of the Allen Institute for Brain Sciences", (http://human.brain-map.org/). The co-expression patterns of DSCR genes in brain were calculated by using multivariate statistical methods.
Results:
Highest levels of gene expression were registered at caudate nucleus, nucleus accumbens and putamen among central areas of cerebral cortex. Increased expression levels of RCAN1 that encode by a protein involved in signal transduction process of the CNS were recorded for PCP4 that participates in the binding to calmodulin and TTC3; a protein that is associated with differentiation of neurons. That previously idenjpgied brain structures play a crucial role in the learning process, in different class of memory and in motor skills.
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- Julio César Montoya, Juliana Soto, José María Satizábal, Adalberto Sánchez, Felipe García, Genomic study of the critical region of chromosome 21 associated to Down syndrome , Colombia Medica: Vol. 42 No. 1 (2011)
Accepted 2014-12-19
Published 2014-12-30
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