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Monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined.


Transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed.


Monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found.


Monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.

Rossana Villegas Gracia, Universidad de Córdoba

Docente tiempo completo programa de Bacteriología, universidad de Córdoba.

Catalina Franco Alzate, Universidad CES

Médico Patólogo,  Docente Facultad de Medicina Universidad CES

Javier Rendón Henao, Universidad de Antioquia

Universidad de Antioquia

José Domingo Torres Hernández, Universidad de Antioquia

Médico Hematólogo, Docente Facultad de Medicina, Universidad de Antioquia

Patricia Elena Jaramillo Arbelaez, Universidad de Antioquia

Bacterióloga, MSc en Microbiología y Bioanálisis énfasis Hematología, Docente Escuela Microbiología Universidad de Antioquia
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Received 2015-01-29
Accepted 2016-05-04
Published 2024-06-07