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Authors

Background:

Post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized.

Objective:

To describe the clinical response, overall and graft survival of patients in our center with this complication after kidney transplantation, which received rituximab as part of their treatment as well as conversion to m-TOR.

Methods:

Retrospective study, which included patients, diagnosed with post-transplant lymphoproliferative disorders after kidney transplantation from January 2011 to July 2014.

Results:

Eight cases were found with a wide spectrum of clinical presentations. Most had monomorphic histology, 85% were associated with Epstein-Barr virus, 25% of patients had tumor involvement of the renal graft, and 12.5% ​​had primary central nervous system lymphoma. All patients were managed with reduction of immunosuppression, conversion to m-TOR (except one who lost the graft at diagnosis) and rituximab-based therapy. The overall response rate was 87.5% (62.5% complete response, 25% partial response). Survival was 87.5% with a median follow-up of 34 months. An additional patient lost the graft, with chronic nephropathy already known. All the remaining patients had stable renal function.

Conclusions:

There are no standardized treatment regimens for lymphoproliferative disorders after kidney transplantation, but these patients can be managed successfully with reduction of immunosuppression, conversion to m-TOR and rituximab-based schemes.

John Fredy Nieto-Rios, 1 Hospital Pablo Tobon Uribe, Medellin,Colombia 2 Universidad de Antioquia, Medellin, Colombia

1-Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia

2 Universidad de Antioquia, Medellin, Colombia

1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia

Sandra Milena Gómez de los Ríos, Universidad Pontificia Bolivariana, Medellin, Colombia

Universidad Pontificia Bolivariana, Medellin, Colombia

Lina María Serna-Higuita, 1 Hospital Pablo Tobon Uribe, Medellin,Colombia 2 Universidad de Antioquia, Medellin, Colombia

1-Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia

2 Universidad de Antioquia, Medellin, Colombia

Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia

Catalina Ocampo-Kohn, 1 Hospital Pablo Tobon Uribe, Medellin,Colombia 2 Universidad de Antioquia, Medellin, Colombia

1-Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia

2 Universidad de Antioquia, Medellin, Colombia

Arbey Aristizabal-Alzate, 1 Hospital Pablo Tobon Uribe, Medellin,Colombia 2 Universidad de Antioquia, Medellin, Colombia

1-Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia

2 Universidad de Antioquia, Medellin, Colombia

Kenny Mauricio Gálvez-Cárdenas, 1 Hospital Pablo Tobon Uribe, Medellin,Colombia

Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia

Gustavo Adolfo Zuluaga-Valencia, 1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia 2 Universidad de Antioquia, Medellin, Colombia

1 Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
Sección Nefrología, Hospital Pablo Tobon Uribe, Medellin,Colombia
2 Universidad de Antioquia, Medellin, Colombia
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Received 2015-06-21
Accepted 2017-01-02
Published 2024-06-11