Bevacizumab as a treatment for hereditary hemorrhagic telangiectasia in children: a case report

https://doi.org/10.25100/cm.v48i2.2719
Telangiectasia Hereditary Hemorrhagic Bevacizumab Osler-Rendu-Weber Disease Pediatrics

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Published: Jun 28, 2017
Issue: Vol. 48 No. 2 (2017)
Section Case Report

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Authors
  • Fabio E Ospina +
  • Alex Echeverri +
  • Iván Posso-Osorio +
  • Lina Jaimes +
  • Jaiber Gutierrez +
  • Gabriel Jaime Tobón +
Abstract
Case description: Five-year-old female patient with hereditary hemorrhagic telangiectasia.Clinical Findings:  Deterioration of cardiopulmonary function with higher oxygen requirements secondary to pulmonary arteriovenous shunts, epistaxis.Treatment and Outcome: The patient was treated with the monoclonal antibody bevacizumab, which inhibits the vascular endothelial growth factor, with good clinical outcome.Clinical Relevance: Hereditary hemorrhagic telangiectasia is an autosomal dominant disorder characterized by arteriovenous malformations in different organs, making its clinical presentations varied. Systemic therapeutic options for a generalized disease are limited. The monoclonal antibody bevacizumab, seems to be a good option in this disorder. Although reported as successful in adult population, its use in pediatric population has not yet been reported. Here we report the use of bevacizumab in a 5-year-old female patient with hereditary hemorrhagic telangiectasia, showing clinical benefits and good outcome.
Author Biographies

Fabio E Ospina, -Fundación Valle del Lili, Cali, Colombia. -Universidad Icesi. Cali, Colombia.

-Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.

- Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Fundación Valle del Lili, Cali, Colombia.

-Facultad de Ciencias de la Salud, Universidad Icesi. Cali, Colombia.

Alex Echeverri, -Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia. -Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Fundación Valle del Lili, Cali, Colombia. Fundación Valle del Lili, Cali, Colombia.

Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.2 Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Fundación Valle del Lili, Cali, Colombia.

Iván Posso-Osorio, -Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia. -Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Fundación Valle del Lili, Cali, Colombia. -Facultad de Ciencias de la Salud, Universidad Icesi. Cali, Colombia.

-Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.-Departamento de Reumatologia, Grupo de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional (GIRAT). Fundación Valle del Lili, Cali, Colombia.-Facultad de Ciencias de la Salud, Universidad Icesi. Cali, Colombia.

Lina Jaimes, Fundación Valle del Lili, Cali, Colombia.

-Departamento de Pediatría, Fundación Valle del Lili, Cali, Colombia.

Jaiber Gutierrez, Fundación Valle del Lili, Cali, Colombia.

-Departamento de Pediatría, Fundación Valle del Lili, Cali, Colombia.

Gabriel Jaime Tobón, -Fundación Valle del Lili, Cali, Colombia. -Universidad Icesi. Cali, Colombia.

-Instituto de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.

-Facultad de Ciencias de la Salud, Universidad Icesi. Cali, Colombia.

How to Cite
Ospina, F. E., Echeverri, A., Posso-Osorio, I., Jaimes, L., Gutierrez, J., & Tobón, G. J. (2017). Bevacizumab as a treatment for hereditary hemorrhagic telangiectasia in children: a case report. Colombia Médica, 48(2), 88–93. https://doi.org/10.25100/cm.v48i2.2719
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Received 2016-11-26
Accepted 2017-04-04
Published 2017-06-28

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