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  1. Home /
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  3. Vol 50 No 4 (2019) /
  4. Original Articles

Association between metabolic syndrome and euthyroid nodular goiter: a case-control study

  • Abstract
  • Keywords
  • Author Biographies
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Abstract

Background: Metabolic syndrome is a cluster of metabolic abnormalities and abdominal obesity; its pathophysiologic basis, insulin resistance, has been shown to act as agent in thyroid cell proliferation. Few studies analyze the relationship between metabolic syndrome and thyroid nodular disease, with a substantial knowledge gap.

Objetive: Determine the association between metabolic syndrome and nodular thyroid disease in a region with adequate iodine intake.

Methods: Case-control study. A total of 182 patients referred to radiology to undergo thyroid ultrasonography due to suspicion of thyroid disease. Cases had at least one thyroid nodule greater than 3 mm (n= 91). Controls did not have evidence of thyroid nodules (n= 91).

Results: Bivariate analysis showed a significant association between metabolic syndrome and the presence of thyroid nodule (OR 2.56, 95% CI: 1.41-4.66, p <0.05). Low levels of HDL (OR 2.81, 95% CI: 1.54-5.12, p <0.05) and impaired fasting glucose (OR 2.05, 95%CI 1.10 to 3.78, p <0.05) were significantly associated with the presence of thyroid nodule, independent of the presence of metabolic syndrome. Multivariate analysis maintained the association between metabolic syndrome and thyroid nodule with an OR of 2.96 (95%CI 1.47 to 5.95, p <0.05); similarly, the associations of low levels of HDL (OR 2.77, 95%CI 1.44 to 5.3, p <0.05) and impaired fasting glucose (OR 2.23, 95%CI 1.14 to 4.34, p<0.05) with thyroid nodule remained significant.

Conclusion: The thyroid nodular disease is associated with increased risk of metabolic syndrome, specifically decreased HDL and impaired fasting glucose levels were the factors that increased association was found.

Authors

  • Wilmer Gianfranco Silva Caso -Universidad Peruana de Ciencias Aplicadas -Centro de Investigación e Innovación de la Facultad de Ciencias de la Salud - UPC- Centro de Salud Las Palmas - Tingo María - Ministerio de Salud del Perú https://orcid.org/0000-0003-1086-8084
  • Raisa A. Mayers Universidad Peruana de Ciencias Aplicadas https://orcid.org/0000-0002-2834-0256
  • Andrea Soria Montoya Universidad Peruana de Ciencias Aplicadas Médico Asistencial en Clínica Angloamericana https://orcid.org/0000-0001-8223-713X
  • Alejandro Piscoya Rivera - Hospital Guillermo Kaelin de la Fuente, EsSalud Gastroenterology service- Universidad Peruana de Ciencias Aplicadas – Lima, Perú https://orcid.org/0000-0002-4420-2419

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Keywords

  • Thyroid Nodule
  • Metabolic Syndrome
  • Insulin Resistance
  • Case-control study.
  • Iodine
  • Obesity
  • Cholesterol
  • Insulin
  • human Insulin-Like Growth Factor II
  • IGF2 protein
  • human Insulin-Like Growth Factor I
  • IGF1 protein

Author Biographies


, -Universidad Peruana de Ciencias Aplicadas -Centro de Investigación e Innovación de la Facultad de Ciencias de la Salud - UPC- Centro de Salud Las Palmas - Tingo María - Ministerio de Salud del Perú

Professor of Facultad de medicina.

Researcher of the Centro de Investigación e Innovación - UPC

orcid_id22.png  https://orcid.org/0000-0003-1086-8084


, Universidad Peruana de Ciencias Aplicadas

orcid_id21.png https://orcid.org/0000-0002-2834-0256


, Universidad Peruana de Ciencias Aplicadas Médico Asistencial en Clínica Angloamericana

orcid_id23.png https://orcid.org/0000-0001-8223-713X


, - Hospital Guillermo Kaelin de la Fuente, EsSalud Gastroenterology service- Universidad Peruana de Ciencias Aplicadas – Lima, Perú

orcid_id23.png https://orcid.org/0000-0002-4420-2419

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Published
2020-01-21
Submitted
2017-01-03
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How to Cite
Silva Caso, W., Mayers, R., Soria Montoya, A., & Piscoya Rivera, A. (2020). Association between metabolic syndrome and euthyroid nodular goiter: a case-control study. Colombia Médica, 50(4), 239-51. https://doi.org/10.25100/cm.v50i4.2833
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Vol 50 No 4 (2019)
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