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Authors

Introduction:

In preterm newborn, problems with the interpretation of 17-OHP may occur.

Objective:

Evaluate 17-OHP values in healthy preterm newborns until they reach the corrected gestational age.

Methods:

Longitudinal study of 36 preterm infants with 17-OHP evaluation using ELISA from heel blood from 3 to 5 days and thereafter every 2 weeks until the corrected gestational age. Values adjusting multiple variables such as gestational age, birth weight and sex, among others were compared. The results were analyzed against 82 healthy full-term infants.

Results:

In the first week of life, early term infants born within less than 34 months of gestational age show 17-OHP values that are much higher than the full term neonates. After a week, the values decrease and stabilize, but are still higher than those of full term neonates and remain so even at the corrected gestational age. (average difference of 63.0%, IC 95%: 11.8%-115.5%). 33.6% (41 samples) of a total of 122 samples taken from preterm infants were higher than 30 ng/mL.

Conclusions:

17-OHP values in early term infants are higher than those in full term neonates and can be related to postnatal adaptive processes. It is suggested that a second screening at the 37th week of corrected age be performed.

Víctor Clemente Mendoza-Rojas, Universidad Industrial de Santander, Bucaramanga, Colombia

Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Luis Alfonso Díaz-Martínez, Universidad Industrial de Santander, Bucaramanga, Colombia

Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Gerardo Mantilla-Mora, Universidad Industrial de Santander, Bucaramanga, Colombia

Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Gustavo Adolfo Contreras-García, Universidad Industrial de Santander, Bucaramanga, Colombia

Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Victor Manuel Mora-Bautista, Universidad Industrial de Santander, Bucaramanga, Colombia

Programa de Especialización en Pediatría, Departamento de Pediatría, Escuela de Medicina; Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

John Freddy Martínez-Paredes, Universidad Industrial de Santander, Bucaramanga, Colombia

Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Alba Lucía Calderón-Rojas, Universidad Industrial de Santander, Bucaramanga, Colombia

Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Carlos Arturo Gómez-Tarazona, Universidad Industrial de Santander, Bucaramanga, Colombia

Programa de Medicina, Escuela de Medicina, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia

Katherine Pinzón-Mantilla, Universidad Industrial de Santander, Bucaramanga, Colombia

Programa de Microbiología y Análisis Clínico, Escuela de Microbiología, Facultad de Salud, Universidad Industrial de Santander, Bucaramanga, Colombia
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Received 2017-01-20
Accepted 2017-11-14
Published 2024-06-05