Polypharmacy among HIV infected people aged 50 years or older
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Introduction: Although HAART cannot eradicate HIV, it suppresses viral replication, resulting in a progressive reduction in HIV-related morbidity and mortality. The increase in life expectancy for HIV-infected patients has turned this disease into a chronic disease and, therefore, to the appearance of comorbidities. At the same time there is an increase in the use of concomitant medication, making HIV-infected patient a polymedicated patient.
Objective: To determine the degree of polypharmacy and to describe clinically relevant drug interactions, as well as the comorbidities and adherence to HAART in HIV + patients over 50 years.
Methods: Observational, transversal study. Patients ≥50 years on HAART ambulatory were included. The variables were collected: aged, sex, VL, CD4, comorbidities, ARV, concomitant medication, herbal products and adherence. Patients who did not sign informed consent were excluded.
Results: Were included 154 patients ≥50 years on HAART. The presence of polypharmacy, defined as the use of 5 or more medications including HAART, was 40.3%. 73.4% of the patients had concomitant medication: lipid-lowering agents (33.8%), anxiolytics / sedatives (28.6%), proton-pump inhibitors (26.0%) antihypertensive agents (23.4%). 102 relevant interactions were recorded, finding statistically significant differences in relation to the presence of polypharmacy and pharmacologic drugs classes (p <0.001).
Conclusion: The prevalence of polypharmacy among HIV+ patients ≥50 years is high. Comorbidities, interactions and drugs associated were similar to those described in the literature. It is necessary to establish priorities in relation to drug interactions with polypharmacy and a correct approach to the pathologies that may develop.
- Higly active atiretroviral therapy
- Drug Interactions
- Comorbidities
- Aging
- Polipharmacy
- Drug prescriptions
- HAART
- Pharmacovigilance
Sonia Fernández Cañabate, Complejo Asistencial Universitario de León, Servicio de Farmacia, León, España
Complejo Asistencial Universitario de León, Servicio de Farmacia, León, España
Luis Ortega Valín, Complejo Asistencial Universitario de León, Servicio de Farmacia, León, España
Complejo Asistencial Universitario de León, Servicio de Farmacia, León, España
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