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We aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-β, +3954 C>T) and tooth movement, in a group of Colombian patients undergoing surgically accelerated orthodontic tooth movement.


The study was nested to a controlled clinical trial. Blood samples were taken from 11 women and 29 healthy Colombian male volunteers between 18 and 40 years old, after 1 year of starting orthodontic treatment. The patients presented malocclusion class I, with grade II or III. To detect the genetic polymorphism of the nucleotide +3954 C to T in the IL-1β gene, we used a real-time PCR assay.


Eleven individuals presented the allele 2 (T) heterozygous with the allele 1 (T/C) and 19 individuals were homozygous for the allele 1 (C/C). When analyzing the presence of the SNP, no significant differences were found in any of the variables. The best treatment was reflected in Group 3 (selective upper and lower alveolar decortication and 3D collagen matrix) and Group 4 (only selective alveolar decortication in the upper arch, with 3D collagen matrix), with 27% and 35% more speed respectively than in the control group.


Our analyses indicated that a reduction in the total treatment time can be mostly potentiated by using decortication and collagen matrices and not for the presence of the allele 2 in the IL-1β. Nevertheless, it is important that further studies investigate if the polymorphism could be associated with the speed of tooth movement and analyze the baseline protein levels.

Juan Fernando Aristizabal, Universidad del Valle. Cali, Colombia


Dentist, Specialist in Orthodontics and Candidate for Master's Degree in Dental Sciences
He is full professor and director of the Department of Orthodontics at the Universidad del Valle, Cali Colombia. In addition, he is a visiting professor at the CES University, Medellin; the University of Antioquia, Medellin; the Santo Tomas University, Bucaramanga and the Central University of Ecuador, Quito.

Research Area

Orthodontics and maxillary orthopedics


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7. Aristizábal, J. F., Ríos, H., Rey, D., Álvarez, M. A., Patiño, B. P., & Ortiz, M. (2019). Interleukin 1-beta (IL-1 [beta]) polymorphism and orthodontics: a systematic review/Polimorfismo de la interleuquina 1 beta (IL-1 [beta]) y ortodoncia: revision sistematica. Revista Facultad de Odontologia, 31(1-2), 81-96.

Hector Rios, School of Dentistry, University of Michigan,

Hector F. Rios D.D.S., Ph.D. is an Assistant Professor in the Department of Periodontics and Oral Medicine at the University of Michigan. Dr. Rios received his dental degree at the University of Valle, Cali-Colombia. He completed his periodontics residency at the University of Michigan and earned an interdisciplinary PhD in Oral Biology and Molecular Biology at the University of Missouri-Kansas City. He is a Diplomate of American Board of Periodontology and maintains a faculty practice limited to periodontics and dental implants in Ann Arbor, Michigan. His research focuses on the molecular dynamics of the periodontium and alveolar bone and their application in regenerative therapy.

Diego Rey, Universidad CES, Facultad de Odontología, Departmento de Ortodoncia. Medellin, Colombia.

Dentist graduated from Universidad CES with a specialty in Orthodontics from New York University

Professor of Orthodontics at the Faculty of Dentistry, Universidad CES . Medellin, Antioquia


Maria Antonia Alvarez, Universidad CES, Facultad de Odontología, Departmento de Ortodoncia. Medellin, Colombia.

Universidad CES, Facultad de
Odontología, Departmento de Ortodoncia. Medellin, Colombia

Beatriz Parra, Universidad del Valle. Cali, Colombia

Bacteriologist, with a master's degree in microbiology from the Universidad del Valle and PhD in Molecular Microbiology And Immunology from the University Of Southern California.

Full professor of the Department of Microbiology of the Faculty of Health of the Universidad del Valle


Mario Ortiz, Universidad del Valle. Cali, Colombia

Dentist, specialist in Orthodontics and Master in Biomedical science

Assistant Professor of the Department of Morphology of the Faculty of Health of the Universidad del Valle


Aristizabal, J. F., Rios, H., Rey, D., Alvarez, M. A., Parra, B., & Ortiz, M. (2024). Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique. Colombia Medica, 51(1), e–4141. (Original work published June 2, 2020)


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Received 2020-01-05
Accepted 2020-05-20
Published 2024-05-17