Tpeak-Tend, Tpeak-Tend dispersion and Tpeak-Tend/QT in children and its relationship with clinical variables
Article Sidebar
Main Article Content
Aim: To characterize the Tpeak-Tend, the Tpeak-Tend dispersion and Tpeak-Tend/QT in children and its relationship with clinical variables.
Methods: Cross-sectional study in 126 children between 9 and 12 years of the Camilo Cienfuegos School in Santa Clara, Cuba. Clinical and anthropometric variables were obtained to determine their relationship with electrocardiographic parameters: Tpeak-Tend V5, Tpeak-Tend dispersion and Tpeak-Tend/QT ratio V5. In addition, laboratory tests were conducted.
Results: Age and systolic blood pressure are associated with an increased probability of having values of Tpeak-Tend/QT V5 ≥75 percentile for both sexes (OR: 1.72, CI 95%: 1.02-2.91; p= 0.043), (OR: 1.08, CI 95%: 1.01-1.16; p= 0.017) respectively. The body mass index and systolic blood pressure are linearly and significantly correlated with the Tpeak-Tend/QT V5 (r= 0.224; p= 0.012) and (r= 0.220; p= 0.014) respectively.
Conclusions: The age of the patients and the systolic blood pressure figures are factors that increase the probability of having values of the Tpeak-Tend/QT V5 ≥75 percentile. There was a significant linear correlation between the Tpeak-Tend/QT V5 with the body mass index and the systolic blood pressure.
Yaniel Castro-Torres, Hospital Universitario Celestino Hernández Robau, Servicio de Cardiología. Santa Clara , Villa Clara. Cuba
https://orcid.org/0000-0003-2019-284XRaimundo Carmona-Puerta, Cardiocentro Ernesto Che Guevara, Servicio de Electrofisiología y Estimulación Cardiaca. Santa Clara, Villa Clara. Cuba.
https://orcid.org/0000-0003-2246-1089Elibet Chávez-González, Cardiocentro Ernesto Che Guevara, Servicio de Electrofisiología y Estimulación Cardiaca. Santa Clara, Villa Clara. Cuba.
Emilio Francisco González-Rodríguez, Universidad Central Marta Abreu de las Villas, Facultad de Ingeniería Eléctrica, Centro de Desarrollo Electrónico. Santa Clara, Villa Clara. Cuba
https://orcid.org/0000-0002-7495-3483Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Wataru S , et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007; 48: 1114-9. https://doi.org/10.1016/j.hrthm.2007.05.028
Antzelevitch C, Di Diego JM, Argenziano M, et al. Tpeak-Tend as a predictor of ventricular arrhythmogenesis. Int J Cardiol. 2017; 249: 75-6. https://doi.org/10.1016/j.ijcard.2017.09.005
Tse G, Gong M, Wong WT, Georgopoulos S, Letsas KP, Vassiliou VS, et al. The Tpeak-Tend interval as an electrocardiographic risk marker of arrhythmic and mortality outcomes: A systematic review and meta-analysis. Heart Rhythm. 2017; 14: 1131-7 https://doi.org/10.1016/j.hrthm.2017.05.031
Yamaguchi M, Shimizu M, Ino H, Terai H, Uchiyama K, Oe K, et al. T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity. Clin Sci (Lond). 2003; 105: 671-6. https://doi.org/10.1042/CS20030010
Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, Dorantes Sánchez M, Dorticós Balea F, Zayas Molina R, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol. 2006; 47: 1828-34. https://doi.org/10.1016/j.jacc.2005.12.049
Hetland M, Haugaa KH, Sarvari SI, Erikssen G, Kongsgaard E, Edvardsen T. A novel ECG-index for prediction of ventricular arrhythmias in patients after myocardial infarction. Ann Noninvasive Electrocardiol. 2014; 19: 330-7. https://doi.org/10.1111/anec.12152
Morin DP, Saad MN, Shams OF, Owen JS, Xue JQ, Abi-Samra FM, et al. Relationships between the T-peak to T-end interval, ventricular tachyarrhythmia, and death in left ventricular systolic dysfunction. Europace. 2012; 14: 1172-9. https://doi.org/10.1093/europace/eur426
Gupta P, Patel C, Patel H, Narayanaswamy S, Malhotra B, Green JT, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol. 2008; 41: 567-74. https://doi.org/10.1016/j.jelectrocard.2008.07.016
Braschi A, Abrignani MG, Francavilla VC, Abrignani V, Francavilla G. Age-and sex-based reference ranges for non-invasive ventricular repolarisation parameters. Int J Clin Pract. 2017; 71: e12949. https://doi.org/10.1111/ijcp.12949
Haarmark C, Kyvik KO, Vedel-Larsen E, Budtz-Jørgensen E, Kanters JK. Heritability of Tpeak-Tend interval and T-wave amplitude. A Twin Study. Circ Cardiovasc Genet. 2011; 4: 516-22. https://doi.org/10.1161/CIRCGENETICS.111.959551
Braschi A, Abrignani MG, Francavilla VC, Francavilla G. Novel electrocardiographic parameters of altered repolarization in uncomplicated overweight and obesity. Obesity. 2011; 19: 875-81. https://doi.org/10.1038/oby.2010.252
Nigro G, Russo V, Di Salvo G, De Crescenzo I, Rago A, Perrone L, et al. Increased heterogenity of ventricular repolarization in obese nonhypertensive children. PACE. 2010; 33: 1533-9. https://doi.org/10.1111/j.1540-8159.2010.02889.x
Wang TJ, Parise H, Levy D, D'Agostino RB Sr, Wolf PA, Vasan RS, et al. Obesity and the risk of new-onset atrial fibrillation. JAMA. 2004; 292: 2471-2477. https://doi.org/10.1001/jama.292.20.2471
Seyfeli E, Duru M, Kuvandik G, Kaya H, Yalcin F. Effect of obesity on P-wave dispersion and QT dispersion in women. Int J Obes (Lond). 2006; 30: 957-61. https://doi.org/10.1038/sj.ijo.0803233
Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, et al. ESH/ESC Guidelines for the management of hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2013; 34: 2159-219. https://doi.org/10.1093/eurheartj/eht151
Demir M, Uyan U. Evaluation of Tp-e interval and Tp-e/QT ratio in patients with non-dipper hypertension. Clin Exp Hypertens. 2014; 36: 285-8. https://doi.org/10.3109/10641963.2013.810233
Salles GF, Cardoso CR, Leocadio SM, Muxfeldt ES. Recent ventricular repolarization markers in resistant hypertension: are they different from the traditional QT interval? Am J Hypertens. 2008 ; 21: 47-53. https://doi.org/10.1038/ajh.2007.4
Kavey RE. Left ventricular hypertrophy in hypertensive children and adolescents: predictors and prevalence. Curr Hypertens Rep. 2013; 15: 453-7. https://doi.org/10.1007/s11906-013-0370-3
Jolly SE, Koller KR, Metzger JS, Day GM, Silverman A, Hopkins SE, et al. Prevalence of hypertension and associated risk factors in western Alaska native people: The Western Alaska Tribal Collaborative for Health (WATCH) Study. J Clin Hypertens (Greenwich). 2015; 17: 812-8. https://doi.org/10.1111/jch.12483
Downloads
The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use