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  1. Home /
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  3. Vol 52 No 3 (2021) /
  4. Reviews

New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology

  • Abstract
  • Keywords
  • Author Biography
  • References

Abstract

Gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. For a long time, its developmental, etiological, and epidemiological aspects have been a hot topic of controversy. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge.

To expand the frontier of knowledge about a malformation that has shown a growing global prevalence, we have conducted a review of the medical literature that gathers information on the embryonic development of the ventral body wall, the primitive intestine and the ring-umbilical cord complex, as well as on the theories about its origin, pathogenesis and recent epidemiological evidence, for which we consulted bibliographic databases and standard search engines.

Authors

  • Lilian Chuaire-Noack Universidad del Valle https://orcid.org/0000-0003-0156-2577

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Keywords

  • Gastroschisis
  • abdominal abnormalities
  • Vitelline Duct
  • Ectopia Cordis
  • Genetic Predisposition to Disease

Author Biography


, Universidad del Valle

orcid_id14.png https://orcid.org/0000-0003-0156-2577

References

Calder J. Two examples of children with preternatural conformation of the guts. Medical Essays and observations, Vol I. T, W Ruddimans, Medical Society of Edinburgh. 1733; 1:203

Curry JI, McKinney P, Thornton JG, Stringer MD. The aetiology of gastroschisis. BJOG. 2000; 107(11): 1339-1346. https://doi.org/10.1111/j.1471-0528.2000.tb11645.x

Torres US, Portela-Oliveira E, Braga F del C, Werner H Jr, Daltro PA, Souza AS. When closure fails: what the radiologist needs to know about the embryology, anatomy, and prenatal imaging of ventral body wall defects. Semin Ultrasound CT MR. 2015; 36(6): 522-536. https://doi.org/10.1053/j.sult.2015.01.001

Chesley PM, Ledbetter DJ, Meehan JJ, Oron AP, Javid PJ. Contemporary trends in the use of primary repair for gastroschisis in surgical infants. Am J Surg. 2015; 209(5): 901-905. https://doi.org/10.1016/j.amjsurg.2015.01.012

Bhat V, Moront M, Bhandari V. Gastroschisis: A State-of-the-Art Review. Children (Basel). 2020; 7(12):302. https://doi.org/10.3390/children7120302

Mandelia A, Agarwala S, Sharma N, Solanki S, Panda S. Left-sided Gastroschisis: A rare congenital anomaly. J Clin Diagn Res. 2013; 7(10): 2300-2302. https://doi.org/10.7860/JCDR/2013/6161.3505

Schierz IAM, Pinello G, Giuffrè M, Corsello G. An unusual association of left-sided gastroschisis and persistent right umbilical vein. Clin Case Rep. 2018; 6(12): 2511-2512. https://doi.org/10.1002/ccr3.1897

Feldkamp ML, Carey JC, Sadler TW. Development of gastroschisis: review of hypotheses, a novel hypothesis, and implications for research. Am J Med Genet Part A. 2007; 639-652. https://doi.org/10.1002/ajmg.a.31578

Sadler TW. The embryologic origin of ventral body wall defects. Semin Pediatr Surg. 2010; 19(3): 209-214. https://doi.org/10.1053/j.sempedsurg.2010.03.006

Stevenson RE, Rogers RC, Chandler JC, Gauderer MW, Hunter AG. Escape of the yolk sac: a hypothesis to explain the embryogenesis of gastroschisis. Clin Genet. 2009; 75(4): 326-333. https://doi.org/10.1111/j.1399-0004.2008.01142.x

Melov SJ, Tsang I, Cohen R, Badawi N, Walker K, Soundappan SSV et al. Complexity of gastroschisis predicts outcome: epidemiology and experience in an Australian tertiary centre. BMC Pregnancy Childbirth. 2018; 18(1): 1-9. https://doi.org/10.1186/s12884-018-1867-1

Salinas-Torres VM, Salinas-Torres RA, Cerda-Flores RM, Martínez-de-Villarreal LE. Familial occurrence of gastroschisis: a population-based overview on recurrence risk, sex-dependent influence, and geographical distribution. Pediatr Surg Int. 2018; 34(3): 277-282. https://doi.org/10.1007/s00383-018-4224-6

Salinas-Torres VM, Gallardo-Blanco HL, Salinas-Torres RA, Cerda-Flores RM, Lugo-Trampe JJ, Villarreal-Martínez DZ et al. Bioinformatic Analysis of gene variants from gastroschisis recurrence identifies multiple novel pathogenetic pathways: implication for the closure of the ventral body wall. Int J Mol Sci. 2019; 20(9): 2295. https://doi.org/10.3390/ijms20092295

Feldkamp ML, Krikov S, Gardner J, Madsen MJ, Darlington T, Sargent R et al. Shared genomic segments in high‐risk multigenerational pedigrees with gastroschisis. Birth Defects Res. 2019; 111(20): 1655-1664. https://doi.org/10.1002/bdr2.1567

Sadler TW. Langman Embriología Médica, 14ª edición. Philadelphia: Wolters Kluwer. 2019. p 84, p 97-100

Sadler TW, Feldkamp ML. The embryology of body wall closure: Relevance to gastroschisis and other ventral body wall defects. Am J Med Genetics Part C (Seminars in Medical Genetics). 2008; 148C (3): 180-185. https://doi.org/10.1002/ajmg.c.30176

Burke AC, Nowicki JL. A new view of patterning domains in the vertebrate mesoderm. Dev Cell. 2003; 4: 159-165. https://doi.org/10.1016/S1534-5807(03)00033-9

Bargy F, Beaudoin S. Comprehensive developmental mechanisms in gastroschisis. Fetal Diagn Ther. 2014; 36: 223-230. https://doi.org/10.1159/000360080

Duhamel B. Embryology of exomphalos and allied malformations. Arch Dis Child. 1963; 38:142-147. https://doi.org/10.1136/adc.38.198.142

Shaw A. The myth of gastroschisis. J Pediatr Surg. 1975; 10: 235-244. https://doi.org/10.1016/0022-3468(75)90285-7

De Vries PA. The pathogenesis of gastroschisis and omphalocele. J Pediatr Surg. 1980; 15(3): 245-251. https://doi.org/10.1016/S0022-3468(80)80130-8

Hoyme HE, Higginbottom MC, Jones KL. The vascular pathogenesis of gastroschisis: intra uterine interruption of the omphalomesenteric artery. J Pediatr. 1981; 98(2): 228-231. https://doi.org/10.1016/S0022-3476(81)80640-3

Lubinsky, M. A vascular and thrombotic model of gastroschisis. Am J of Med Genet Part A. 2014; 164A: 915-917. https://doi.org/10.1002/ajmg.a.36370

Kluth D, Lambrecht W. The pathogenesis of omphalocele and gastroschisis: An unsolved problem. Pediatr Surg Int. 1996; 11(2-3): 62-66. https://doi.org/10.1007/BF00183727

Rittler M, Vauthay L, Mazzitelli N. Gastroschisis is a defect of the umbilical ring: evidence from morphological evaluation of stillborn fetuses. Birth Defects Res A Clin Mol Teratol. 2013; 97(4): 198-209. https://doi.org/10.1002/bdra.23130

Beaudoin S. Insights into the etiology and embryology of gastroschisis. Semin Pediatr Surg. 2018; 27(5): 283-288. https://doi.org/10.1053/j.sempedsurg.2018.08.005

Opitz JM, Feldkamp ML, Botto LD. An evolutionary and developmental biology approach to gastroschisis. Birth Defects Res. 2019; 111(6): 294-311. https://doi.org/10.1002/bdr2.1481

Saxonhouse MA, Kays DW, Burchfield DJ, Hoover R, Islam S. Gastroschisis with jejunal and colonic atresia, and isolated colonic atresia in dichorionic, diamniotic twins. Pediatr Surg Int. 2009; 25(5): 437-439. https://doi.org/10.1007/s00383-009-2353-7

Binet A, Ceaux E, Bory JP, Poli-Merol ML, François-Fiquet C. Recurrence of pregnancies with gastroschisis: a case report. Arch Pediatr. 2015; 22(10):1039-1041. https://doi.org/10.1016/j.arcped.2015.07.011

Annual report. International Clearing House of birth defect surveillance and research 2014. En: http://www.icbdsr.org/wp-content/annual_report/Report2014.pdf. Último acceso: abril 30 de 2021

Feldkamp ML, Arnold KE, Krikov S, Reefhuis J, Almli LM, Moore CA et al. Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997-2011. BMJ Open. 2019; 9: e026297. https://doi.org/10.1136/bmjopen-2018-026297

Yazdy MM, Mitchell AA, Werler MM. Maternal genitourinary infections and the risk of gastroschisis. Am J Epidemiol. 2014; 180(5): 518-525. https://doi.org/10.1093/aje/kwu157

Parker SE, Werler MM, Gissler M, Surcel HM. Maternal antibodies to Chlamydia trachomatis and risk of gastroschisis. Birth Defects Res. 2017; 109(8): 543-549. https://doi.org/10.1002/bdr2.1001

Ahrens KA, Anderka MT, Feldkamp ML, Canfield MA, Mitchell AA, Werler MM. National Birth Defects Prevention Study. Antiherpetic medication use and the risk of gastroschisis: findings from the National Birth Defects Prevention Study, 1997-2007. Paediatr Perinat Epidemiol. 2013; 27(4): 340-345. https://doi.org/10.1111/ppe.12064

Werler MM, Parker SE, Hedman K, Gissler M, Ritvanen A, Surcel HM. Maternal antibodies to herpes virus antigens and risk of gastroschisis in offspring. Am J Epidemiol. 2016; (12): 902-912.. https://doi.org/10.1093/aje/kww114

Waller SA, Paul K, Peterson SE, Hitti JE. Agricultural-related chemical exposures, season of conception, and risk of gastroschisis in Washington State. Am J Obstet Gynecol. 2010; 202: 241-246. https://doi.org/10.1016/j.ajog.2010.01.023

Agopian AJ, Langlois PH, Cai Y, Canfield MA, Lupo PJ. Maternal residential atrazine exposure and gastroschisis by maternal age. Matern Child Health J. 2013; 17: 1768-1775. https://doi.org/10.1007/s10995-012-1196-3

Kielb C, Lin S, Herdt-Losavio M, Bell E, Chapman B, Rocheleau CM et al. National Birth Defects Prevention Study. Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects. Int J Hyg Environ Health. 2014; 217(2-3): 248-254. https://doi.org/10.1016/j.ijheh.2013.06.003

Souther C, Puapong DP, Woo R, Johnson SM. Possible etiologies of increased incidence of gastroschisis. Pediatr Surg Int. 2017; 33(11): 1209-1213. https://doi.org/10.1007/s00383-017-4166-4

Müller WU, Streffer C. Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation. Teratology. 1990; 42: 643-650. https://doi.org/10.1002/tera.1420420609

Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T et al. Maternal treatment with opioid analgesics and risk for birth defects. Am J Obstet Gynecol. 2011; 204: 314-321. https://doi.org/10.1016/j.ajog.2010.12.039

Short TD, Stallingastrosquisis EB, Isenburg J, O'Leary LA, Yazdy MM, Bohm MK et al. Gastroschisis trends and ecologic link to opioid prescription rates - United States, 2006-2015. MMWR Morb Mortal Wkly Rep. 2019; 68(2): 31-36. https://doi.org/10.15585/mmwr.mm6802a2

Purnamasari D, Setyowati S, Yunir E, Khumaedi AI, Harbuwono DS. Gastroschisis following treatment with high-dose methimazole in pregnancy: a case report. Drug Saf Case Rep. 2019; 6(1): 5. https://doi.org/10.1007/s40800-019-0099-2

Lin S, Munsie JP, Herdt-Losavio ML, Bell E, Druschel C, Romitti PA et al. National Birth Defects Prevention Study. Maternal asthma medication use and the risk of gastroschisis. Am J Epidemiol. 2008; 168(1): 73-79. https://doi.org/10.1093/aje/kwn098

Centofanti SF, Francisco RPV, Phillippi ST, Galletta MAK, Sousa AMS, Rodrigues AS et al. Maternal nutrient intake and fetal gastroschisis: A case-control study. Am J Med Genet A. 2019; 179(8): 1535-1542. https://doi.org/10.1002/ajmg.a.61265

Paranjothy S, Broughton H, Evans A, Huddart S, Drayton M, Jefferson R et al. The role of maternal nutrition in the aetiology of gastroschisis: an incident case-control study. Int J Epidemiol. 2012; 41: 1141-1152. https://doi.org/10.1093/ije/dys092

Palmer SR, Evans A, Broughton H, Huddart S, Drayton M, Rankin J et al. The role of maternal stress in early pregnancy in the aetiology of gastroschisis: an incident case control study. PLoS One. 2013; 8(11): e80103. https://doi.org/10.1371/journal.pone.0080103

Carmichael SL, Ma C, Tinker S, Shaw GM; National Birth Defects Prevention Study. Maternal stressors and social support and risks of delivering babies with gastroschisis or hypospadias. Am J Epidemiol. 2017; 185(12):1240-1246. https://doi.org/10.1093/aje/kww121

Hernández-Trejo M, Montoya-Estrada A, Torres-Ramos Y, Espejel-Núñez A, Guzmán-Grenfell A, Morales-Hernández R et al. Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates. BMC Immunol. 2017; 18(1):3. https://doi.org/10.1186/s12865-016-0184-6

Toboła-Wróbel K, Pietryga M, Dydowicz P, Napierała M, Brązert J, Florek E. Association of oxidative stress on pregnancy. Oxid Med Cell Longev. 2020:6398520. https://doi.org/10.1155/2020/6398520

Werler MM, Guéry E, Waller DK, Parker SE. Gastroschisis and cumulative stressor exposures. Epidemiology. 2018; 29(5):721-728.https://doi.org/10.1097/EDE.0000000000000860

Williams LJ, Kucik JE, Alverson CJ, Olney RS, Correa A. Epidemiology of gastroschisis in metropolitan Atlanta, 1968 through 2000. Birth Defects Res. A Clin Mol Teratol. 2005;73(3):177-183. https://doi.org/10.1002/bdra.20114

Jones AM, Isenburg J, Salemi JL, Arnold KE, Mai CT, Aggarwal D et al. Increasing Prevalence of Gastroschisis--14 States, 1995-2012. MMWR Morb Mortal Wkly Rep. 2016;65(2):23-26. https://doi.org/10.15585/mmwr.mm6502a2

Stallings EB, Isenburg JL, Short TD, Heinke D, Kirby RS, Romitti PA et al. Population-based birth defects data in the United States, 2012-2016: A focus on abdominal wall defects. Birth Defects Res. 2019;111(18):1436-1447. https://doi.org/10.1002/bdr2.1607

Clark RH, Sousa J, Laughon MM, Tolia VN. Gastroschisis prevalence substantially decreased from 2009 through 2018 after a 3-fold increase from 1997 to 2008. J Pediatr Surg. 2020;55(12):2640-2641. https://doi.org/10.1016/j.jpedsurg.2020.03.010

Li N, Chen YL, Li J, Li LL, Jiang CZ, Zhou C et al. Decreasing prevalence and time trend of gastroschisis in 14 cities of Liaoning Province: 2006-2015. Sci Rep. 2016; 6:33333. https://doi.org/10.1038/srep33333

Informe de eventos defectos congénitos, Colombia, semestre I 2019. Instituto Nacional de Salud. En: https://www.ins.gov.co. Ultimo acceso: 24/04/2021

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Published
2021-11-19
Submitted
2020-02-25
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How to Cite
Chuaire-Noack, L. (2021). New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology. Colombia Médica, 52(3), e4004227. https://doi.org/10.25100/cm.v52i3.4227
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