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Gastroschisis is a congenital structural defect of the abdominal wall, most often to the right of the umbilicus, through which the abdominal viscera protrude. For a long time, its developmental, etiological, and epidemiological aspects have been a hot topic of controversy. However, recent findings suggest the involving of genetic and chromosomal alterations and the existence of a stress-inducing pathogenetic pathway, in which risk factors such as demographic and environmental ones can converge.


To expand the frontier of knowledge about a malformation that has shown a growing global prevalence, we have conducted a review of the medical literature that gathers information on the embryonic development of the ventral body wall, the primitive intestine and the ring-umbilical cord complex, as well as on the theories about its origin, pathogenesis and recent epidemiological evidence, for which we consulted bibliographic databases and standard search engines.

Lilian Chuaire-Noack, Universidad del Valle

orcid_id14.png https://orcid.org/0000-0003-0156-2577

Chuaire-Noack, L. (2024). New clues to understand gastroschisis. Embryology, pathogenesis and epidemiology. Colombia Medica, 52(3), e4004227. https://doi.org/10.25100/cm.v52i3.4227 (Original work published November 19, 2021)

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Received 2020-02-25
Accepted 2021-11-06
Published 2024-04-18