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Authors


Background:


Whole-brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) are two treatment modalities commonly utilized to treat brain metastases (BMs).




Aim:


The purpose of this study is to analyze retrospectively the local control and survival of patients with BMs of breast cancer (BC) treated via radiosurgery using Volumetric Modulated Arc Therapy (VMAT-RS).




Methods:


18 patients with 41 BMs of BC and treated by VMAT-RS were studied. They were classified according to the molecular subtype of BC and the modified breast graded prognostic assessment -GPA- index. Patients presented 1-4 BMs, which were treated with 5 non-coplanar VMAT arcs. The spatial distribution of BMs, the influence of receptor status on the location of the lesions and survival assessed via the Kaplan-Meier model were analyzed.




Results:


The median survival time (MST) was 19.7 months. Statistically significant differences were determined in the MST according to the Karnofsky performance status (p= 0.02) and the HER2 status (p= 0.004), being more prolonged in the HER2+ patients. Finally, our results showed that the cerebellum is the predominant site of breast cancer BMs, and also suggested that HER2+BMs had a predilection for some structures of the posterior circulation, such as the cerebellum, brainstem and occipital lobes (p= 0.048).




Conclusions:


The VMAT-RS is a technique with an overall survival compared to other radiosurgery techniques. The baseline situation at the time of treatment, the modified breast-GPA and the molecular subtypes are factors that significantly influence patient survival.


José Manuel Sánchez-Villalobos, Universidad de Murcia, University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Murcia, Spain, 2 University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Neurology, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0002-4617-0211

Alfredo Serna-Berna, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Medical Physics and Radiation Protection, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0003-3584-1478

Juan Salinas-Ramos, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain

orcid_id14.png https://orcid.org/0000-0001-8137-575X

Pedro Pablo Escolar-Pérez, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain

orcid_id14.png https://orcid.org/0000-0002-7142-1772

Emma Martínez-Alonso, University of Murcia, Faculty of Medicine/Dentistry, Department of Cell Biology and Histology, Biomedical Research Institute of Murcia, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0002-8121-0442

Daniel Gyingiri Achel, Ghana Atomic Energy Commission, Radiological and Medical Sciences Research Institute, Applied Radiation Biology Centre, Legon-Accra, Ghana.

orcid_id14.png https://orcid.org/0000-0001-7152-8177

Miguel Alcaraz, University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0003-3095-4756

Sánchez-Villalobos, J. M., Serna-Berna, A., Salinas-Ramos, J., Escolar-Pérez, P. P., Martínez-Alonso, E., Achel, D. G., & Alcaraz, M. (2024). Volumetric modulated arc radiosurgery for brain metastases from breast cancer: A single-center study. Colombia Medica, 52(3), e2004567. https://doi.org/10.25100/cm.v52i3.4567 (Original work published June 28, 2021)

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Received 2020-09-24
Accepted 2021-05-05
Published 2024-04-18