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  1. Home /
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  3. Vol 52 No 3 (2021) /
  4. Original Articles

Volumetric modulated arc radiosurgery for brain metastases from breast cancer: A single-center study

  • Abstract
  • Keywords
  • Author Biographies
  • References

Abstract

Background:

Whole-brain radiation therapy (WBRT) and stereotactic radiosurgery (SRS) are two treatment modalities commonly utilized to treat brain metastases (BMs).

Aim:

The purpose of this study is to analyze retrospectively the local control and survival of patients with BMs of breast cancer (BC) treated via radiosurgery using Volumetric Modulated Arc Therapy (VMAT-RS).

Methods:

18 patients with 41 BMs of BC and treated by VMAT-RS were studied. They were classified according to the molecular subtype of BC and the modified breast graded prognostic assessment -GPA- index. Patients presented 1-4 BMs, which were treated with 5 non-coplanar VMAT arcs. The spatial distribution of BMs, the influence of receptor status on the location of the lesions and survival assessed via the Kaplan-Meier model were analyzed.

Results:

The median survival time (MST) was 19.7 months. Statistically significant differences were determined in the MST according to the Karnofsky performance status (p= 0.02) and the HER2 status (p= 0.004), being more prolonged in the HER2+ patients. Finally, our results showed that the cerebellum is the predominant site of breast cancer BMs, and also suggested that HER2+BMs had a predilection for some structures of the posterior circulation, such as the cerebellum, brainstem and occipital lobes (p= 0.048).

Conclusions:

The VMAT-RS is a technique with an overall survival compared to other radiosurgery techniques. The baseline situation at the time of treatment, the modified breast-GPA and the molecular subtypes are factors that significantly influence patient survival.

Authors

  • José Manuel Sánchez-Villalobos Universidad de Murcia, University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Murcia, Spain, 2 University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Neurology, Murcia, Spain. https://orcid.org/0000-0002-4617-0211
  • Alfredo Serna-Berna University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Medical Physics and Radiation Protection, Murcia, Spain. https://orcid.org/0000-0003-3584-1478
  • Juan Salinas-Ramos University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain https://orcid.org/0000-0001-8137-575X
  • Pedro Pablo Escolar-Pérez University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain https://orcid.org/0000-0002-7142-1772
  • Emma Martínez-Alonso University of Murcia, Faculty of Medicine/Dentistry, Department of Cell Biology and Histology, Biomedical Research Institute of Murcia, Murcia, Spain. https://orcid.org/0000-0002-8121-0442
  • Daniel Gyingiri Achel Ghana Atomic Energy Commission, Radiological and Medical Sciences Research Institute, Applied Radiation Biology Centre, Legon-Accra, Ghana. https://orcid.org/0000-0001-7152-8177
  • Miguel Alcaraz University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. https://orcid.org/0000-0003-3095-4756

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Keywords

  • Volumetric Modulated Arc Therapy
  • Whole-brain radiation therapy
  • Radiosurgery
  • Brain metastasis
  • Triple Negative Breast Neoplasms
  • Receptors, Progesterone
  • Radiation Oncology
  • Radiotherapy, Intensity-Modulated
  • ErbB Receptors

Author Biographies


, Universidad de Murcia, University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Murcia, Spain, 2 University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Neurology, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0002-4617-0211


, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Medical Physics and Radiation Protection, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0003-3584-1478


, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain

orcid_id14.png https://orcid.org/0000-0001-8137-575X


, University Hospital Complex of Cartagena (Santa Lucia University Hospital - Santa María del Rosell University Hospital), Department of Radiation Oncology, Murcia, Spain

orcid_id14.png https://orcid.org/0000-0002-7142-1772


, University of Murcia, Faculty of Medicine/Dentistry, Department of Cell Biology and Histology, Biomedical Research Institute of Murcia, Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0002-8121-0442


, Ghana Atomic Energy Commission, Radiological and Medical Sciences Research Institute, Applied Radiation Biology Centre, Legon-Accra, Ghana.

orcid_id14.png https://orcid.org/0000-0001-7152-8177


, University of Murcia, Faculty of Medicine/Dentistry, Department of Radiology and Physical Medicine, Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.

orcid_id14.png https://orcid.org/0000-0003-3095-4756

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Published
2021-06-28
Submitted
2020-09-24
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How to Cite
Sánchez-Villalobos, J. M., Serna-Berna, A., Salinas-Ramos, J., Escolar-Pérez, P., Martínez-Alonso, E., Achel, D., & Alcaraz, M. (2021). Volumetric modulated arc radiosurgery for brain metastases from breast cancer: A single-center study. Colombia Médica, 52(3), e2004567. https://doi.org/10.25100/cm.v52i3.4567
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Vol 52 No 3 (2021)
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