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Insulin acts on metabolisms and normal growth. In the past decades, its effects on central nervous system functions, such as: appetite-satiety cycle modulation, reproductive function, neurotransmitter release, neuronal survival and synaptic plasticity have been discovered. Evidences got from animal models and neuropathologic findings, have elucidated a fraction of the mechanism that associates insulin signal with neurodegenerative syndromes, like Alzheimer disease. Here, insulin action on hypothalamus, neuron survival, synaptic plasticity and implications of this knowledge on understanding degenerative process of central nervous system particularly Alzheimer disease, will be reviewed.

Andrés Jagua, Universidad Nacional de Colombia

Estudiante, Quinto semestre de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.

Rafael Alejandro Marín, Universidad Nacional de Colombia

Médico Cirujano, Universidad Nacional de Colombia, Bogotá, Colombia.

Luis Alexander Granados, Universidad Nacional de Colombia

Residente, Tercer año de Neurología Clínica, Universidad Nacional de Colombia, Bogotá, Colombia.

Vladimir Avila, Universidad Nacional de Colombia

Docente Auxiliar, Universidad Nacional y Universidad Antonio Nariño, Bogotá, Colombia.
Jagua, A., Marín, R. A., Granados, L. A., & Avila, V. (2008). Brain insulin. Colombia Médica, 39(1), 107–116.


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