Association between calcium intake, parathormone levels and blood pressure during pregnancy.
Calcium intake Endothelin PTH PTH-rp Preeclampsia Nitric oxide
Article Sidebar
Main Article Content
Purpose: To evaluate the association between calcium intake from diet, calciotropic hormones (PTH, PTH-rp), vasoactive regulators (endothelin, nitric oxide) and blood pressure levels during pregnancy, birth and puerperium.
Method: In a prospective study 149 healthy normotensive primigravidas were followed-up from 15 weeks of gestation to puerperium. Daily calcium intake, calciuria, PTH, PTH-rp, endothelin, nitrite-nitrate, and Holter Test were assessed. Linear regression models were performed to evaluate the association between calcium intake, blood pressure levels and the laboratory tests. Multivariate regression models were performed to control potential confounders.
Results: A significant increase of calcium intake during pregnancy was observed (931±301 mg/day to 1,195±467 mg/day, p< 0.001). Plasma PTH-rp, endothelin, and nitrite-nitrate levels did not change during pregnancy. Among the women 38 (25.4%) had low calcium intake (< 800 mg/day) with a larger increase of systolic and diastolic blood pressure during pregnancy (p=0.04) birth (p=0.006) and puerperium (p=0.01). After adjusting for other factors the multivariate analyses showed statistical association between low calcium intake, high parathormone levels and high systolic blood pressure levels during pregnancy (p=0.002).
Conclusion: Low calcium intake during pregnancy is associated with a larger increase of systolic blood pressure and high parathormone levels.
Method: In a prospective study 149 healthy normotensive primigravidas were followed-up from 15 weeks of gestation to puerperium. Daily calcium intake, calciuria, PTH, PTH-rp, endothelin, nitrite-nitrate, and Holter Test were assessed. Linear regression models were performed to evaluate the association between calcium intake, blood pressure levels and the laboratory tests. Multivariate regression models were performed to control potential confounders.
Results: A significant increase of calcium intake during pregnancy was observed (931±301 mg/day to 1,195±467 mg/day, p< 0.001). Plasma PTH-rp, endothelin, and nitrite-nitrate levels did not change during pregnancy. Among the women 38 (25.4%) had low calcium intake (< 800 mg/day) with a larger increase of systolic and diastolic blood pressure during pregnancy (p=0.04) birth (p=0.006) and puerperium (p=0.01). After adjusting for other factors the multivariate analyses showed statistical association between low calcium intake, high parathormone levels and high systolic blood pressure levels during pregnancy (p=0.002).
Conclusion: Low calcium intake during pregnancy is associated with a larger increase of systolic blood pressure and high parathormone levels.
Nieto, A., Herrera, J. A., Villar, J., Matorras, R., López de la Manzanara, C., Arribas, I., Alvarez, J., & Peiró, E. (2009). Association between calcium intake, parathormone levels and blood pressure during pregnancy. Colombia Medica, 40(2), 185–193. https://doi.org/10.25100/cm.v40i2.641
Downloads
Download data is not yet available.
- Julián A. Herrera, Evaluación del riesgo obstétrico en el cuidado prenatal. , Colombia Medica: Vol. 33 No. 1 (2002)
- Julio C. Klinger, Julián A. Herrera, María L. Díaz, Andrés A. Jhann, Gloria I. Avila, Clara I. Tobar, La psiconeuroinmunología en el proceso salud enfermedad. , Colombia Medica: Vol. 36 No. 2 (2005)
- César A. Guevara, Diana P. Henao, Julián A. Herrera, Síndrome de desgaste profesional en médicos internos y residentes. Hospital Universitario del Valle, Cali, 2002. , Colombia Medica: Vol. 35 No. 4 (2004)
- Julián A. Herrera, Carlos H. Moreno, Comportamiento gráfico de la presión arterial diastólica durante el embarazo en gestantes con riesgo de preeclampsia. , Colombia Medica: Vol. 31 No. 4 (2000)
- Jesús J. Magallanes, Adolfo León Vaca, Liliana Arias, Julián A. Herrera, Prácticas de salud y su relación con las características sociofamiliares de estudiantes de medicina. Universidad del Valle, Cali, Colombia, 1994 , Colombia Medica: Vol. 26 No. 4 (1995)
- Julián A. Herrera, Santiago Vélez Medina, Rodolfo Molano, Virna Medina, Javier E. Botero, Beatriz Parra, Adolfo Contreras, Periodontal intervention effects on pregnancy outcomes in women with preeclampsia. , Colombia Medica: Vol. 40 No. 2 (2009)
- Elsa Lucía Tejada de Azuero, Julián A. Herrera, Carlos Hugo Moreno, Identificación temprana de riesgo cardiovascular y de cáncer por pruebas-filtro de laboratorio en funcionarios de la Universidad del Valle, Cali, Colombia 1999-2000. , Colombia Medica: Vol. 31 No. 3 (2000)
- Julián A. Herrera, Myriam Arévalo Herrera, Adriana Villegas, Sócrates Herrera, Maribel Villalba, Arnoldo Bromet, Calcium oral supplementation in adolescent pregnant women. , Colombia Medica: Vol. 37 No. 2 Supl 1 (2006)
- José I. Montaño, Ximena Dossman, Julián A. Herrera, Arnoldo Bromet, Carlos H. Moreno, Helicobacter pylori and psychosocial stress in patients with chronic gastritis. , Colombia Medica: Vol. 37 No. 2 Supl 1 (2006)
- José Mauricio Ocampo, Julián A. Herrera, Patricia Torres, Jhon Alexander Rodríguez, Liliana Loboa, Carlos Alberto García, Caregiver burden in dependent elderly. , Colombia Medica: Vol. 38 No. 1 (2007)
The copy rights of the articles published in Colombia Médica belong to the Universidad del Valle. The contents of the articles that appear in the Journal are exclusively the responsibility of the authors and do not necessarily reflect the opinions of the Editorial Committee of the Journal. It is allowed to reproduce the material published in Colombia Médica without prior authorization for non-commercial use