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Purpose: To evaluate the association between calcium intake from diet, calciotropic hormones (PTH, PTH-rp), vasoactive regulators (endothelin, nitric oxide) and blood pressure levels during pregnancy, birth and puerperium.
Method: In a prospective study 149 healthy normotensive primigravidas were followed-up from 15 weeks of gestation to puerperium. Daily calcium intake, calciuria, PTH, PTH-rp, endothelin, nitrite-nitrate, and Holter Test were assessed. Linear regression models were performed to evaluate the association between calcium intake, blood pressure levels and the laboratory tests. Multivariate regression models were performed to control potential confounders.
Results: A significant increase of calcium intake during pregnancy was observed (931±301 mg/day to 1,195±467 mg/day, p< 0.001). Plasma PTH-rp, endothelin, and nitrite-nitrate levels did not change during pregnancy. Among the women 38 (25.4%) had low calcium intake (< 800 mg/day) with a larger increase of systolic and diastolic blood pressure during pregnancy (p=0.04) birth (p=0.006) and puerperium (p=0.01). After adjusting for other factors the multivariate analyses showed statistical association between low calcium intake, high parathormone levels and high systolic blood pressure levels during pregnancy (p=0.002).
Conclusion: Low calcium intake during pregnancy is associated with a larger increase of systolic blood pressure and high parathormone levels.

Aníbal Nieto, Universidad de Alcalá

Associate Professor, Department of Obstetrics and Gynaecology, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

Julián A. Herrera, Universidad del Valle

Professor Emeritus, Head Department of Family Medicine, Universidad del Valle, Cali, Colombia. Honorary Professor, Obstetrics & Gynecology, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

José Villar, WHO

HRP Research Program, WHO, Geneva, Switzerland.

Roberto Matorras, Universidad del País Vasco

Assistant Professor, Department of Obstetrics and Gynecology, Hospital de Cruces, Universidad del País Vasco, Bilbao, España.

Carlos López de la Manzanara, Universidad de Alcalá,

Associate Professor, Department of Obstetrics and Gynaecology, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

Ignacio Arribas, Universidad de Alcalá,

Clinical Analysis Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.

Julia Alvarez, Universidad de Alcalá

Department of Obstetrics and Gynecology, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid, España.

Eugenia Peiró, Universidad de Alcalá

Clinical Analysis Department, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
Nieto, A., Herrera, J. A., Villar, J., Matorras, R., López de la Manzanara, C., Arribas, I., Alvarez, J., & Peiró, E. (2009). Association between calcium intake, parathormone levels and blood pressure during pregnancy. Colombia Medica, 40(2), 185–193. https://doi.org/10.25100/cm.v40i2.641

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