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Objective: to quantify placenta-specific RNA in plasma of women carrying foetuses with intrauterine growth restriction and

pregnant women with normal pregnancies.

Materials and methods: 8 pregnant women with foetuses with intrauterine growth restriction were studied as well as 18

women with uncomplicated pregnancies in the third pregnancy trimester. Total free RNA was quantified in maternal plasma

by spectrophotometry and the gene expression of hPL (Human Placental Lactogen) at the messenger RNA level through

technical Real Time-Chain Reaction Polymerase.

Results: plasma RNA of fetoplacental origin was successfully detected in 100% of pregnant women. There were no statistically

significant differences between the values of total RNA extracted from plasma (p = 0.5975) nor in the messenger RNA

expression of hPL gene (p = 0.5785) between cases and controls.

Conclusion: messenger RNA of fetoplacental origin can be detected in maternal plasma during pregnancy.


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Received 2011-09-12
Accepted 2012-02-17
Published 2012-09-28