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Introduction: There are few studies that describe the effects of cannabinoids in the gastric system, although in only one, there was the description of a gastric pH alteration.
Objective: To determine the anti-secretory effect of the species Cannabis sativa.
Methodology: In this study forty five Sprague Dawley rats were used, they were submitted to a 24 hours fasting period, after which the pylorus was ligated for 2-4 hours, according to the experimental group. Thereafter, the rats were anesthetized, their stomachs extirpated and the gastric content analyzed for volume and pH.
Results: The Cannabis extract raised the gastric pH when compared to the control group (p < 0.05), with no significant differences found between the reference drug (ranitidine) and the Cannabis extract (p >0.05). There were no differences in the measured volumes.
Conclusions: These results suggest that the Cannabis sativa extract diminishes the gastric acid output.

Germán Gabriel Castillo, Universidad del Valle

Médico Interno, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Harry Mauricio Pachajoa, Universidad del Valle

Médico Interno, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Sandra Eliana Villota, Universidad del Valle

Médico Interno, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Edwin Zurita, Universidad del Valle

Médico Interno, Escuela de Medicina, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Mauricio Palacios, Universidad del Valle

Profesor Asistente, Departamento de Farmacología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Oscar Gutiérrez, Universidad del Valle

Profesor Asistente, Jefe Sección de Farmacología, Escuela de Ciencias Básicas, Facultad de Salud, Universidad del Valle, Cali, Colombia.
Castillo, G. G., Pachajoa, H. M., Villota, S. E., Zurita, E., Palacios, M., & Gutiérrez, O. (2006). Study of the gastric acid anti-secretory activity of Cannabis sativa in an animal model. Colombia Medica, 37(4), 254–257. https://doi.org/10.25100/cm.v37i4.454

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