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Background: Amyloid light chain (AL) amyloidosis is characterized by amyloid fibril deposition derived from monoclonal immunoglobulin light chains, resulting in multiorgan dysfunction. Limited data exist on the clinical features of AL amyloidosis.


Objective: This study aims to describe the clinical characteristics, treatments, and outcomes in Colombian patients with AL amyloidosis.


Methods: A retrospective descriptive study was conducted at three high-complexity centers in Medellín, Colombia. Adults with AL amyloidosis diagnosed between 2012 and 2022 were included. Clinical, laboratory, histological, treatment, and survival data were analyzed.


Results: The study included 63 patients. Renal involvement was most prevalent (66%), followed by cardiac involvement (61%). Multiorgan involvement occurred in 61% of patients. Amyloid deposition was most commonly detected in renal biopsy (40%). Bortezomib-based therapy was used in 68%, and 23.8% received high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDCT-ASCT). Hematological response was observed in 95% of patients with available data. Cardiac and renal organ responses were 15% and 14%, respectively. Median overall survival was 45.1 months (95% CI: 22.2-63.8).


In multivariate analysis, cardiac involvement was significantly associated with inferior overall survival (HR 3.27; 95% CI: 1.23-8.73; p=0.018), HDCT-ASCT had a non-significant trend towards improved overall survival (HR 0.25; 95% CI: 0.06-1.09; p=0.065).


Conclusions: In this study of Colombian patients with AL amyloidosis, renal involvement was more frequent than cardiac involvement. Overall survival and multiorgan involvement were consistent with data from other regions of the world. Multivariate analysis identified
cardiac involvement and HDCT-AHCT as possible prognostic factors.

Jorge Andrés Lacouture Fierro, Hospital San Vicente, Fundación Rionegro, Departamento de Hematología, Rionegro, Colombia.2 Universidad de Antioquia, Sección de Hematología Clínica, Departamento de Medicina interna, Facultad de Medicina, Medellín, Colombia

orcid_id14.png https://orcid.org/0000-0002-8398-5807

Daniel Andrés Ribero Vargas, 1. Universidad de Antioquia

orcid_id14.png https://orcid.org/0000-0002-5402-4599

Juanita Sánchez Cano, Hospital Pablo Tobón Uribe; Medellín; Colombia

orcid_id14.png  https://orcid.org/0009-0003-0133-4088

Lina Maria Gaviria Jaramillo, 1. Universidad de Antioquia, Sección de Hematología Clínica, Departamento de Medicina interna, Facultad de Medicina, Medellín, Colombia 2. Hospital San Vicente Fundación Medellín, Departamento de Hematología, Medellín, Colombia

orcid_id14.png  https://orcid.org/0000-0001-6748-6971

Oliver Gerardo Perilla Suarez, Universidad de Antioquia

orcid_id14.png   https://orcid.org/0000-0001-8399-7253

Kenny Mauricio Galvez Cárdenas, Hospital Pablo Tobón Uribe, Departamento de Hematología, Medellín, Colombia.

orcid_id14.png  https://orcid.org/0000-0003-1192-9053

Sigifredo Ospina Ospina, Universidad de Antioquia

orcid_id14.pnghttps://orcid.org/0000-0003-1192-9053

Lacouture Fierro, J. A., Ribero Vargas, D. A., Sánchez Cano, J., Gaviria Jaramillo, L. M., Perilla Suarez, O. G., Galvez Cárdenas, K. M., & Ospina Ospina, S. (2023). Clinical characterization and outcomes of a cohort of colombian patients with AL Amyloidosis. Colombia Medica, 54(3), e2025667. https://doi.org/10.25100/cm.v54i3.5667 (Original work published September 30, 2023)

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Received 2023-07-05
Accepted 2023-10-24
Published 2023-12-18