Renin angiotensin system. Physiological and pathophysiological considerations
Main Article Content
The renin-angiotensin system functions a an important regulator of cardiovascular homeostasis. When recently discovered, it was considered a circulating endocrine system. Nowadays, it's known that many of their constituents are synthesized in several] tissues, exerting such different roles on them that they have been classified in circulating and titular systems. The main organs it is localized are the heart, brain, kidney, blood vessels, adrenals, etc., where its functions are fairly established. However, the physiologic role of the system at the organs associated with reproduction is not so clear, despite the ANG II receptor localization on them.
- Renina angiotensina
- homeostasis cardiovascular
- circulación pulmonar
Garrison, JC & Peach, MJ. Renin and angiotensin. Pp. 735-746. In The pharmacological basis of therapeutic. 8th ed A. Goodman Gilman et al. (eds.), Pergamon Press Inc., New York,1990.
Dzau, YJ. Tissue renin angiotensin system: physiologic and pharmacologic implications. Circulation, 1988, 77SI: 1-3. DOI: https://doi.org/10.1097/00001573-198801001-00009
Laragh, JH. Concept of antirenin system therapy. Historie perspective. AmJ Med, 1984, 77: 1-6. DOI: https://doi.org/10.1016/S0002-9343(84)80051-0
Campbell, DJ. Circulating and tissue angiotensin systems. J Clin lnvest, 1987, 79: 1-6 DOI: https://doi.org/10.1172/JCI112768
Dzau, VJ. Circulating versus local renin angiotensin system in cardiovascular homeostasis. Circulation, 1988, 77SI: 4-13. DOI: https://doi.org/10.1161/01.CIR.77.5.947
Dzau, VJ, Colucci WS, Williams GH et al. Sustained effectiveness of converting enzyme inhibitors in patients with severe congestive heart failure. N Eng J Med, 1980, 302: 1373-1379. DOI: https://doi.org/10.1056/NEJM198006193022501
Haber, E. The role of renin in normal and pathological cardiovascular homeostasis. Circulation, 1976,54: 849-861. DOI: https://doi.org/10.1161/01.CIR.54.6.849
Lindpaintner, K, Jin, M, Wilhelm, MJ et al. lntracardiac generation of angiotensin and its physiologic role. Circulation, 1988, 77SI: 18-23.
Grinstead, WC & Young, JB: The myocardial renin angiotensin system: existence, importance and clinical implications. Am Heart J, 1992, 123: 1039-1045. DOI: https://doi.org/10.1016/0002-8703(92)90715-8
Nelson, EB, Pool, JL & Taylor, AA. Pharmacology of angiotensin converting enzyme inhibitors. Am J Med, 1986, 81: 13-19. DOI: https://doi.org/10.1016/0002-9343(86)90939-3
Dzau, VJ & Pratt, RE. Renin angiotensin system. Pp. 1817-1849. In The heart and cardiovascular system. 2nd. ed. Fozzard, HA et al., Raven Pre s Ltd. New York,1992.
l2. Dzau, VJ, Ellison, KE, Brody, Tet al. A comparative study of the distributions of renin and angiotensin messenger ribonucleic acids in rat and mouse tissues. Endocrinology, 1987,J 20: 2334-2338. DOI: https://doi.org/10.1210/endo-120-6-2334
Lindpaintner, K & Ganten, D. Toe cardiac renin angiotensin system. An appraisal of preterm experimental and clínica) evidence. Circ Res, 1991. 68: 905-92 1. DOI: https://doi.org/10.1161/01.RES.68.4.905
Dzau, VJ. Cardiac renin angiotensin in the system: molecular and functional aspects. Am J Mee!, 1988, 84: 22-27. DOI: https://doi.org/10.1016/0002-9343(88)90201-X
Lindpaintner, -K, Jin iedem1eyer, N et al. Cardiac angiotensinogen and its local activation in the isolated perfused beating heart. Circ Res, 1990, 67: 564-57 1. DOI: https://doi.org/10.1161/01.RES.67.3.564
Drexler, H, Lindpaintner. K. Lu, W et al. Transient increase in the expression of cardiac angiotensinogen in a rat model of myocardial infarction and failure. Circulation, 1989, 80:
II-450-Il-456.
Saito, K, Gutkind, JS & Saavedra, JM. Angiotensin inhibiting sites in the conduction system of rat hearts. Am J Physiol, l987, 253: Hl6l -Hl622. DOI: https://doi.org/10.1152/ajpheart.1987.253.6.H1618
Baker, KM, Campanille, CP, Trachte, G et al. Identification and characterization of the rabbit angiotensin Il myocardial receptor. Circ Res, 1984, 54: 286-293. DOI: https://doi.org/10.1161/01.RES.54.3.286
Douglas, JG. Angiotensin receptor subtypes of the kidney cortex. Am J Physiol, 1987, 253: FI-F7. DOI: https://doi.org/10.1152/ajprenal.1987.253.1.F1
Unabe, Y, Kent, RL & Mann, DL. The positive inotropic effect of angiotensin II is modulated by protein kinase C. Circulation, 1990, 82: IIl216-III223.
Niliu, B, Hess, P, Lansman, JB et al. A novel type of calcium cardiac channel in ventricular cells. Nature, 1985, 316: 443-446. DOI: https://doi.org/10.1038/316443a0
Malik, KU & Nasjiletti, A. Facilitation of adrenergic transmitter by locally generated angiotensin Il in rat mesenteric arteries. Circ Res, l 975, 38: 26-34. DOI: https://doi.org/10.1161/01.RES.38.1.26
Saxena, PR. Interaction between the renin-angiotensin-aldosterone and ·sympathetic nervous systems (Abstr.). J Cardiovasc Pharmacol, 1992, 16 (Suppl 6): 80. DOI: https://doi.org/10.1097/00005344-199219006-00013
Re, R & Rovigatti, U. New approach to the study of the cellular biology of the cardiovascular system. Circulation, 1988, 77(suppl 1):14-17.
Gavras, H, Kremer, D, Brown, J et al. Angiotensin and norepinephrine-induced myocardial le ions: experimental and clínical studies in rabbit and man. Am Heart J, 1975, 89: DOI: https://doi.org/10.1016/0002-8703(75)90082-4
-327.
DeGraeff, PA, DeLangen, CD, van Gil t, WHetal. Protective effects of captopril against ischemia. Reperfusion-induced arrhythmias in vitro and in vivo. Am J Med, 1988, 84 (suppl 3A): 67-74. DOI: https://doi.org/10.1016/0002-9343(88)90207-0
Moorman, JR, Kirsch, GE & Lacerda, AE. Angiotensin II modulates cardiac sodium channels in neonatal rats. Circ Res, I 988, 65: 1804- I 812. DOI: https://doi.org/10.1161/01.RES.65.6.1804
Bergrnan, G, Atkinson, L, Richardson, PJ et al. Prostacyclin: hemodynamic and metabolic effects in patients with coronary artery disease. Lancet, 1981, 1: 569-572. DOI: https://doi.org/10.1016/S0140-6736(81)92028-6
Friedrnan, PL, Brugada, P, Kuck, KH et al. Coronary vasoconstrictor effect of indomethacin in patients with coronary artery disease. N Eng J Med, 1981, 305: 1171-1175. DOI: https://doi.org/10.1056/NEJM198111123052002
Murthy, VS, Waldron, TL & Goldberg ME. The mechanism of bradykinin potentiation after inhibition of angiotensin-converting enzyme by SQ14,225 in conscious rabbits. Circ Res, 1978, 43 (suppl 1): 40-45.
Rearns, GP. Angiotensin-converting enzyme in renal and cerebral tissue and implications for successful blood pressure management. Am J Cardiol, 1992, 69: 59C-64C. DOI: https://doi.org/10.1016/0002-9149(92)90283-5
Unger, T, Badoer, E, Ganten, D et al. Brain angiotensin: pathways and pharmacology. Circulation, 1988, 77 (suppl 1): 40-54.
Lind, RW, Swanson, LW & Ganten D. Angiotensin II immunoreactivity in the neural afferents and efferents of the subfornical organ of the rat. Brain Res, 1984, 321: 209-215. DOI: https://doi.org/10.1016/0006-8993(84)90174-4
Lind, RW, Swanson, LW, Bruhn, TO et al. The distribution of angiotensin II immunoreactive cells and fibers in the paraventricular-hypophysial system of the rat. Brain Res, 1985, 338: 81-89. DOI: https://doi.org/10.1016/0006-8993(85)90250-1
Fitz irnrnon , JT. Angiotensin stimulation of the central nervous system. Rev Physiol BiochemPharmacol, 1980, 87: 117-167.
Scholkens, BA, Jung, W, Rascher, W et al. Intra-cerebroventricular angiotensin increases arterial blood pre ure in rhesus monkeys by stimulation of pituitary hormones and the sympathetic nervous system. Experientia, 1982, 38: 469-473. DOI: https://doi.org/10.1007/BF01952643
Malayan, SA, Keil, LC, Rarnsay, DJ et al. Mechanism of su pre sion of plasma renin activity by centrally administered angiotensin IJ. Endocrinology, 1979, 104: 672-675. DOI: https://doi.org/10.1210/endo-104-3-672
Casto, R & Phillips, l. Angiotensin attenuates baroreflexes at nucleus tractus solitarius of rats. Am J Physiol, 1986, 250: Rl93-Rl98. DOI: https://doi.org/10.1152/ajpregu.1986.250.2.R193
Strittmatter, SM, Thiele, EA, Kapiloff, MS et al. A rat brain isozyme of angiotensin converting enzyme. J Biol Chem, 1985, 260: 9825-9828. DOI: https://doi.org/10.1016/S0021-9258(17)39310-9
Schelling, P, Meyer, D, Loos, HE et al. A micro method for the measurement of renin in brain nuclei: its application on spontaneously hypertensive rats. Neuropharmacology, 1982, 2/: 455-463. DOI: https://doi.org/10.1016/0028-3908(82)90031-4
Raizada, MK, Muther, TF & Summer, C. lncreased angiotensin II receptor in neuronal cultures from hypertensive rat brain. Am J Physiol, 1984, 247: C364-C372. DOI: https://doi.org/10.1152/ajpcell.1984.247.5.C364
Hollenberg, NK & Williams, GH. Angiotensin and the renal circulation in hypertension. Circulation, 1988, 77S: I-59-1-63.
MacGregor, GA. Blood pressure, angiotensin converting enzyme inhibitors, and the kidney (abstr.). Am J Med, 1992, 92S: 20. DOI: https://doi.org/10.1016/0002-9343(92)90143-Y
Liu, FY & Cogan, MG. Angiotensin 11: a potent regulator of acidification in the rat early proximal convoluted tubule. J Clin Invest, 1987, 80: 272. DOI: https://doi.org/10.1172/JCI113059
Caldicott, WJH, Taub, K, Margulies, S et al. Angiotensin receptors in glomeruli differ from those in renal arterioles. Kidney Int, 1981,19: 687-693. DOI: https://doi.org/10.1038/ki.1981.68
Curtis, JJ, Luke, RJ, Welchel, J. et al. Inhibition of angiotensin-converting enzyme in renal transplant recipients with hypertension. N Eng J Med, 1983, 308: 377-381. DOI: https://doi.org/10.1056/NEJM198302173080707
Hricik, DE, Browning, Rl, Kopelman, RI, et al. Captopril-induced functional renal insufficiency in patients with bilateral renal artery stenosis or renal artery stenosis in the solitary kidney. N Eng J Med, 1983, 308: 373-376. DOI: https://doi.org/10.1056/NEJM198302173080706
Packer, M. Interaction of prostaglandins and angiotensin II in the modulation of renal function in congestive heart failure. Circulation, 1988, 77S: 1-64-I-73.
Oliver, JA & Sciacca, RR. Local generation of angiotensin 11 as a mechanism of regulation of peripheral vascular tone in the rat. J Clin lnvest, 1984, 74: 1247-1251. DOI: https://doi.org/10.1172/JCI111534
N akamaru, N, J ackson, EK & lnagami, T. Beta-adrenoreceptor mediated release of angiotensin II from mesenteric arteries. Aml Physiol, 1986, 250: Hl44-Hl48. DOI: https://doi.org/10.1152/ajpheart.1986.250.1.H144
Melby, JC. Angiotensin-converting enzyme in the cardiovascular and adrenal tissues and implications for successful blood pressure management. Am J Cardiol, 1992, 69: 2C-7C. DOI: https://doi.org/10.1016/0002-9149(92)90275-4
Naftilan, AJ, Pratt, RE & Dzau, VJ. Induction of PDGF A-chain and E-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. J Clin lnvest, 1989,83: 1419-1423. DOI: https://doi.org/10.1172/JCI114032
Williams, GH, McDonnel, LM, Raux MC et al. Evidence for different angiotensin II receptors in rat adrenal glomerulose and rabbit vascular smooth muscle cells. Circ Res, 1974, 34: 383-392. DOI: https://doi.org/10.1161/01.RES.34.3.384
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