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Preeclampsia is a major contributor to maternal mortality, premature birth, intrauterine growth retardation, and perinatal mortality. The exact causes of preeclampsia are unknown, but several epidemiological factors and specific clinical changes in the second trimester of pregnancy have been associated with the disease. This paper briefly reviews epidemiological, immunogenetic, and biochemical factors related to the prevention of the most common and serious pregnancy complications.

Julián A. Herrera M., Profesor Titular, Departamento de Medicina Familiar, Facultad de Salud, Universidad del Valle, Cali, Colombia. 

Profesor Titular, Departamento de Medicina Familiar, Facultad de Salud, Universidad del Valle, Cali, Colombia. 

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